Illuminating the evolutionary history of chlamydiae
Illuminating the evolutionary history of chlamydiae
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DOI：
10.1126/science.1096330
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发表时间：
2004-04-30
期刊：
影响因子：
56.9
通讯作者：
Wagner, M
中科院分区：
文献类型：
--
作者：
Horn, M;Collingro, A;Wagner, M
衣原体是可预防的失明和性传播疾病的主要原因。对自由生活的变形虫衣原体相关共生体的基因组分析显示，它是任何致病性衣原体的两倍大，并且几乎没有最近获得横向基因的迹象。我们发现，大约7亿年前，致病性和共生性衣原体的最后一个共同祖先已经适应了早期真核生物的细胞内生存，并且含有许多在现代致病性衣原体中发现的毒力因子，包括III型分泌系统。古代衣原体似乎是真核细胞利用机制的鼻祖。
Chlamydiae are the major cause of preventable blindness and sexually transmitted disease. Genome analysis of a chlamydia-related symbiont of free-living amoebae revealed that it is twice as large as any of the pathogenic chlamydiae and had few signs of recent lateral gene acquisition. We showed that about 700 million years ago the last common ancestor of pathogenic and symbiotic chlamydiae was already adapted to intracellular survival in early eukaryotes and contained many virulence factors found in modern pathogenic chlamydiae, including a type III secretion system. Ancient chlamydiae appear to be the originators of mechanisms for the exploitation of eukaryotic cells.