DIFFERENTIAL COGNITIVE IMPAIRMENT IN ALZHEIMERS-DISEASE AND HUNTINGTONS-DISEASE
DIFFERENTIAL COGNITIVE IMPAIRMENT IN ALZHEIMERS-DISEASE AND HUNTINGTONS-DISEASE
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DOI：
10.1002/ana.410230605
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发表时间：
1988-06-01
影响因子：
11.2
通讯作者：
FOLSTEIN, MF
中科院分区：
文献类型：
--
作者：
BRANDT, J;FOLSTEIN, SE;FOLSTEIN, MF
皮质和皮质下痴呆之间的区别要求不同原因引起的痴呆的认知特征是可区分的。对于大量阿尔茨海默病和亨廷顿病患者样本，通过简易精神状态检查获得了不同的认知特征。这些特征差异与痴呆症的严重程度无关，并且足以将患者分类为阿尔茨海默氏病或亨廷顿氏病，准确度为 84%。认知功能的质性差异也可能是其他皮质和皮质下痴呆的典型特征。
The differentriation between cortical and subcortical dementias requires that the cognitive charcateristics of dementias attributable to different causes be discriminable. For large samples of Alzheimer''s disease and Huntington''s disease patients, distinct cognitive profiles were obtained on the Mini-Mental State Exam. The profile differences were independent of severity of dementia and were sufficiently robust to classify patients as Alzheimer''s disease or Huntington''s disease with 84% accuracy. The qualitative differences in cognitive functioning may also be typical of other cortical and subcortical dementias.