Regulatory T cells as a potent target for controlling bone loss.
Regulatory T cells as a potent target for controlling bone loss.
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DOI：
10.1016/j.bbrc.2010.09.120
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发表时间：
2010-11
影响因子：
3.1
通讯作者：
Feng-Lai Yuan;Xia Li;Wei-guo Lu;Rui-sheng Xu;Yi-qing Zhao;Cheng-wan Li;Jian-ping Li;Feihu Chen
中科院分区：
文献类型：
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作者：
Feng-Lai Yuan;Xia Li;Wei-guo Lu;Rui-sheng Xu;Yi-qing Zhao;Cheng-wan Li;Jian-ping Li;Feihu Chen
代谢性骨疾病，如类风湿性关节炎（RA）和骨质疏松症，影响全球数亿人，是长期疼痛和残疾的主要原因。由于对导致骨破坏的分子机制的了解不完全，因此缺乏有效的临床治疗骨疾病中的骨破坏。近年来，研究证实调节性T细胞（Regulatory T cells，Tcells）在多种自身免疫性疾病的发病机制中起着重要的免疫抑制作用。在体外，TdR直接抑制破骨细胞的分化和功能。在小鼠中，向TNF转基因小鼠中注射TGFAP导致全身骨密度增强。此外，已经表明，通过过表达FoxP 3增加TbR数量在预防局部和全身性骨破坏中是有效的。用抗CD 28超激动剂抗体进行体内处理导致Tcl 3数量的更强增加，从而保护TNF转基因小鼠免受TNF-α诱导的骨丢失。与此一致的是，在FoxP 3转基因小鼠中，Tglutamine可以控制卵巢切除术诱导的骨丢失。本文将简要讨论Tregs的生物学特征，并总结Tregs在代谢性骨病中骨丢失的发病机制和治疗中的作用的最新进展。
Metabolic bone diseases, such as rheumatoid arthritis (RA) and osteoporosis, affect hundreds and millions of people worldwide leading causes of long-term pain and disability. Effective clinical treatment for bone destruction in bone diseases is lacking because the knowledge about molecular mechanisms leading to bone destruction are incompletely understood. Recently, it has been confirmed that regulatory T cells (Tregs) play a crucial role in suppressing the immune response in the pathogenesis of various autoimmune diseases. In vitro, Tregs directly inhibit osteoclasts and differentiation and function. In mice, the injection of Tregs into the TNF transgenic results in enhanced systemic bone density. In addition, it has been shown that increase of Tregs numbers by overexpressing the FoxP3 is effective in the prevention of local and systemic bone destruction. In vivo treatment with anti-CD28 superagonist antibody leading to a stronger increase in Tregs numbers protect against TNF-a-induced bone loss in TNF-transgenic mice. In agreement, Tregs can control ovariectomy-induced bone loss in FoxP3-transgenic mice. In this paper, we will briefly discuss the biological features of Tregs and summarize recent advances on the role of Tregs in the pathogenesis and treatment of bone loss in metabolic bone diseases.