Transposable elements are found in a large number of human protein-coding genes
Transposable elements are found in a large number of human protein-coding genes
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DOI：
10.1016/s0168-9525(01)02445-3
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发表时间：
2001-11-01
影响因子：
11.4
通讯作者：
Li, WHS
中科院分区：
文献类型：
--
作者：
Nekrutenko, A;Li, WHS
为了研究转座因子（TES）对蛋白质编码区进化的全基因组影响，我们检测了13799个人类基因，在蛋白质编码区发现了533例（约4%）TIES。这些TE中的大多数（类似于89.5%）位于“内含子”内，并被招募到编码区作为新的外显子。我们发现TE整合常常对基因功能有影响。特别是，有两个小鼠基因的编码区主要由TES组成，这表明TE插入可能会产生新的基因。因此，越来越多的证据表明TE在基因进化中起着重要作用。由于许多TE是分类特异性的，它们整合到编码区可能会加速物种分化。
To study the genome-wide impact of transposable elements (TES) on the evolution of protein-coding regions, we examined 13 799 human genes and found 533 (similar to4%) cases of TIES within protein-coding regions. The majority of these TEs (similar to 89.5%) reside within 'introns' and were recruited into coding regions as novel exons. We found that TE integration often has an effect on gene function. In particular, there were two mouse genes whose coding regions consist largely of TES, suggesting that TE insertion might create new genes. Thus, there is increasing evidence for an important role of TEs in gene evolution. Because many TEs are taxon-specific, their integration into coding regions could accelerate species divergence.