Rapid selection for resistance to diamide insecticides in Plutella xylostella via specific amino acid polymorphisms in the ryanodine receptor.
Rapid selection for resistance to diamide insecticides in Plutella xylostella via specific amino acid polymorphisms in the ryanodine receptor.
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DOI：
10.1016/j.neuro.2016.05.012
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发表时间：
2017-05
期刊：
影响因子：
3.4
通讯作者：
Davies TGE
中科院分区：
文献类型：
--
作者：
Troczka BJ;Williamson MS;Field LM;Davies TGE
整理小菜蛾对二胺类杀虫剂的基线敏感性。综述了小菜蛾抗二胺的实例。二胺类杀虫剂对昆虫良胺受体的特异性突出。描述了分离和鉴定小菜黄嘌呤受体的努力。探讨小菜对抗性的分子机制。氟苯二胺、氯虫腈等二胺类杀虫剂是一类具有选择性激活虫胺受体（RyR）的新型杀虫剂。对十字花科蔬菜作物的鳞翅目害虫，包括小菜蛾、小菜蛾有特别的防治作用。然而，在其商业化后相对较短的时间内，在该领域报告了相对大量的控制失败。本文综述了目前关于小菜双胺抗性分子机制的研究进展。从不同国家收集的耐药表型通常可以与ryanodine受体跨膜结构域的特定靶位突变联系起来。抗性的代谢机制也被提出。快速的抗药性发展可能是过度依赖这一类化学物质来控制小菜蛾的结果。
Baseline susceptibility of Plutella xylostella to diamide insecticides collated. Instances of diamide resistance in P. xylostella summarized. Diamide insecticide specificity for the insect ryanodine receptor highlighted. Efforts to isolate and characterize the P. xylostella ryanodine receptor described. Molecular mechanisms of diamide resistance in P. xylostella discussed. Diamide insecticides, such as flubendiamide and chlorantraniliprole, are a new class of insecticide with a novel mode of action, selectively activating the insect ryanodine receptor (RyR). They are particularly active against lepidopteran pests of cruciferous vegetable crops, including the diamondback moth, Plutella xylostella. However, within a relatively short period following their commercialisation, a comparatively large number of control failures have been reported in the field. In this review we summarise the current body of knowledge regarding the molecular mechanisms of diamide resistance in P. xylostella. Resistant phenotypes collected from different countries can often be linked to specific target-site mutation(s) in the ryanodine receptors’ transmembrane domain. Metabolic mechanisms of resistance have also been proposed. Rapid resistance development is probably a consequence of over-reliance on this one class of chemistry for diamondback moth control.