Relationship between vitamin D deficiency and bone fragility in sickle cell disease: A cohort study of 56 adults
Relationship between vitamin D deficiency and bone fragility in sickle cell disease: A cohort study of 56 adults
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DOI：
10.1016/j.bone.2012.10.005
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发表时间：
2013-01-01
期刊：
影响因子：
4.1
通讯作者：
Ribeil, Jean-Antoine
中科院分区：
文献类型：
--
作者：
Arlet, Jean-Benoit;Courbebaisse, Marie;Ribeil, Jean-Antoine
背景：最近的研究表明，镰状细胞病（SCD）患者存在严重的维生素D （VD）缺乏症。关于VD缺乏对这些患者骨脆性影响的数据有限。目的：评估成人SCD患者VD缺乏症的患病率及其对骨代谢和脆性的影响。方法：本前瞻性研究纳入56例SCD成人患者（平均年龄29.8±9.5岁），临床状态稳定。记录临床和实验室数据。采用双x线吸收仪测定骨密度（BMD）。比较两组患者的骨折史、骨密度、无血管性骨坏死、h型椎体和矿物质代谢指标，分别为极低（6 ng/mL, n = 26）（2组）25(OH)D浓度。结果：25(OH)D中位浓度为6 ng/mL。VD缺乏（25(OH)D）
Background: Recent studies suggest that patients with sickle cell disease (SCD) have profound vitamin D (VD) deficiency. Limited data exist on the effect of VD deficiency on bone fragility in these patients.Objectives: To assess the prevalence of VD deficiency in adults with SCD and its consequences on bone metabolism and fragility.Methods: This prospective study included 56 SCD adult patients (mean age 29.8 +/- 9.5 years), in a clinically steady state. Clinical and laboratory data were recorded. Bone mineral density (BMD) was measured using dual X-ray absorptiometry. Fracture history, BMD, avascular osteonecrosis, H-shaped vertebra and markers of mineral metabolism were compared between two groups of patients presenting very low (6 ng/mL, n = 26) (group 2) 25(OH)D concentration, respectively.Results: Median 25(OH)D concentration was 6 ng/mL. VD deficiency (25(OH)D