Behavioral pattern analysis and dopamine release in quinpirole-induced repetitive behavior in rats
Behavioral pattern analysis and dopamine release in quinpirole-induced repetitive behavior in rats
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DOI：
10.1177/0269881110389093
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发表时间：
2011-12-01
影响因子：
4.1
通讯作者：
Westenberg, Herman G. M.
中科院分区：
文献类型：
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作者：
de Haas, Ria;Nijdam, Annelies;Westenberg, Herman G. M.
强迫症 (OCD) 是一种慢性致残性精神疾病，终生患病率为 2-3%。患有强迫症的人会遭受侵入性、不必要的和反复出现的想法（强迫症）和/或重复的仪式行为（强迫症）。本研究的目的是通过使用 T 模式行为分析来量化喹吡罗诱导的大鼠行为中仪式性“强迫性”行为的维度。此外，我们还研究了喹吡罗致敏引起的行为效应在停止治疗两周后是否仍然存在。最后，为了研究这种“强迫性”行为的神经生物学基础，我们研究了喹吡罗治疗对伏隔核细胞外多巴胺水平的影响。一旦建立，“强迫性”行为取决于喹吡罗的给药，因为这种行为在停止治疗后迅速恢复正常。与连续给予喹吡罗治疗的动物相比，单剂量喹吡罗后，经盐水预处理的动物的多巴胺水平下降更多。此外，T 模式分析表明，与强迫症仪式不同，喹吡罗诱导的行为由较小的行为组成。正如在强迫症患者中所见，接受喹吡罗治疗的动物重复执行这些行为的频率很高。这些发现表明，喹吡罗诱导的行为仅模仿了强迫症患者的部分强迫行为。
Obsessive-compulsive disorder (OCD) is a chronic and disabling psychiatric disease with a lifetime prevalence of 2-3%. People with OCD suffer from intrusive, unwanted and recurrent thoughts (obsessions) and/or repetitive ritualistic behaviors (compulsions). The aim of this study is to quantify the dimensions of ritualistic 'compulsive-like' behavior in quinpirole-induced behavior in rats by using T-pattern behavioral analysis. In addition, we investigated whether the behavioral effects elicited by quinpirole sensitization remained after 2 weeks of cessation of treatment. Finally, to study the neurobiological underpinnings of this 'compulsive-like' behavior, we investigated the effect of quinpirole treatment on the extraceltular dopamine levels in the nucleus accumbens. Once established, 'compulsive-like' behavior is dependent upon quinpirole administration, as this behavior rapidly normalized after cessation of treatment. After a single dose of quinpirole the dopamine level decreased more in saline pre-treated animals as compared with animals given quinpirole treatment continuously. Furthermore, T-pattern analysis revealed that quinpirole-induced behavior consists, unlike OCD rituals, of a smaller behavioral repertoire. As seen in patients with OCD, quinpirole-treated animals performed these behaviors with a high rate of repetition. These findings suggest that quinpirote-induced behavior mimics only part of the compulsive behavior as shown in OCD patients.