Endoscopic ultrasound and computed tomography predictors of pancreatic cancer resectability
Endoscopic ultrasound and computed tomography predictors of pancreatic cancer resectability
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DOI：
10.1007/s11605-007-0373-y
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发表时间：
2008-01-01
影响因子：
3.2
通讯作者：
Merchant, Nipun B.
中科院分区：
文献类型：
--
作者：
Bao, Philip Q.;Johnson, J. Chad;Merchant, Nipun B.
简介 本研究调查了超声内镜 (EUS) 和计算机断层扫描 (CT) 预测接受胰十二指肠切除术 (PD) 的患者切缘阴性 (R0) 切除的能力以及静脉切除的必要性。方法 确定了在过去 5 年内接受手术并打算切除的胰头腺癌患者。收集有关血管受累的 EUS 和 CT 数据。将术前影像学与术中发现和最终病理结果进行比较。使用 Fisher 精确检验的列联表分析确定了与不可切除性和阳性切缘相关的 EUS 和 CT 成像特征。结果 76 名患者符合研究标准。四十七人 (62%) 接受了可能治愈的 PD。 R0切除率为70%。有16名因局部晚期疾病而无法手术切除的患者。通过 CT 检测，静脉受累 > 180 度和动脉受累 > 90 度对于未能实现 R0 切除具有 100% 的阳性预测值 (p
Introduction This study investigates the ability of endoscopic ultrasound (EUS) and computed tomography (CT) to predict a margin negative (R0) resection and the need for venous resection in patients undergoing pancreaticoduodenectomy (PD).Methods Patients with pancreatic head adenocarcinoma undergoing surgery with intent to resect during the last 5 years were identified. EUS and CT data on vascular involvement were collected. Preoperative imaging was compared to intraoperative findings and final pathology. Contingency table analysis using Fisher's exact test identified imaging features of EUS and CT associated with unresectability and positive margins.Results Seventy-six patients met study criteria. Forty-seven (62%) underwent potentially curative PD. The R0 resection rate was 70%. There were 16 unresectable patients because of locally advanced disease. Venous involvement > 180 degrees and arterial involvement > 90 degrees by CT had 100% positive predictive value for failure to achieve R0 resection (p