Modification of electrospun PI membranes with active chlorine for antimicrobial skin patches applications
Modification of electrospun PI membranes with active chlorine for antimicrobial skin patches applications
复制标题
用活性氯对电纺 PI 膜进行改性，用于抗菌皮肤贴片应用
DOI：
10.1016/j.apsusc.2022.153302
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发表时间：
2022
影响因子：
6.7
通讯作者：
Sroczyk E
中科院分区：
文献类型：
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作者：
Sroczyk E
特应性皮炎（AD）是一种常见而复杂的疾病，由多种内在因素引起.症状之一是皮肤表面的金黄色葡萄球菌数量增加。这些细菌触发，加速和加剧AD。为了减少炎症，我们设计了抗菌贴片，抑制细菌生长。使用静电纺丝，我们生产的聚酰亚胺（PI）纳米纤维收集在多孔膜的形式。这些PI膜用次氯酸钠（NaOCl）改性。用扫描电子显微镜（SEM）（具有二次电子（SE）模式、背散射电子（BSE）模式）和能量色散X射线（EDX）光谱、傅里叶变换红外光谱（FTIR）和X射线光电子能谱（XPS）确认活性氯含量。此外，我们评估了贴片的润湿性和zeta电位。最后，我们对革兰氏阳性模式生物进行了抗菌效力测定。金黄色葡萄球菌和革兰氏阴性菌大肠杆菌。我们观察到，氯化PI贴片表现出有效的细菌杀灭，使其成为抗微生物皮肤贴片应用的优良材料。
Atopic dermatitis (AD) is a common andcomplex disorder caused by many inherently intractable factors. One of the symptoms is an increased amount ofStaphylococcus aureuson the skin surface. These bacteria trigger, accelerate, and exacerbate AD. In order to reduce inflammation, we designed antimicrobial patches, which inhibit bacterial growth. Using electrospinning, we produced polyimide (PI) nanofibers collected in the form of porous membranes. These PI membranes were modified with sodium hypochlorite (NaOCl). The active chlorine content was confirmed with scanning electron microscopy (SEM) with secondary electrons (SE) mode, backscattered electrons (BSE) mode, and energy-dispersive X-ray (EDX) spectroscopy, with Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). Moreover, we evaluated the wettability and zeta potential of the patches. Finally, we performed an antimicrobial efficacy assay against the Gram-positive model organismS. aureusand the Gram-negative model,Escherichia coli. We observed that the chlorinated PI patches demonstrate effective bacterial killing, making them excellent material for antimicrobial skin patches applications.