Tubulobulbar complex: cytoskeletal remodeling to release spermatozoa.
Tubulobulbar complex: cytoskeletal remodeling to release spermatozoa.
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DOI：
10.1186/1477-7827-10-27
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发表时间：
2012-04-17
期刊：
影响因子：
--
通讯作者：
Balasinor NH
中科院分区：
文献类型：
--
作者：
Upadhyay RD;Kumar AV;Ganeshan M;Balasinor NH
管小球复合体（tbc）是一种以肌动蛋白为基础的结构，有助于在睾丸精管中的支持-支持细胞或成熟的生殖细胞（精子）之间建立密切的接触。它们是富含肌动蛋白的推通装置，可以消除多余的精子细胞质，并准备成熟的精子释放到管腔中。在精子形成之前，细长的精子通过一个广泛的结构与支持细胞相互作用，该结构由各种粘附分子组成，称为顶端外质特化，部分被精子头凹表面的顶端TBC所取代。精子的释放过程涉及广泛的重组，即在精原上皮中支持细胞-精子细胞界面的连接点的拆卸和重组。根据tbc中不同种类分子的存在或在tbc缺失时观察到的缺陷，tbc的主要功能是消除多余的精细胞细胞质，结合分子的内吞噬和再循环，形成精细胞顶体，形成成熟精细胞释放前的瞬时锚定装置。本文综述了近年来有关睾丸精子释放过程中tbc在细胞骨架重构中的作用及其分子机制的研究进展。
Tubulobulbar complexes (TBCs) are actin-based structures that help establish close contact between Sertoli–Sertoli cells or Sertoli–mature germ cells (spermatids) in the seminiferous tubules of the testes. They are actin-rich push-through devices that eliminate excess spermatid cytoplasm and prepare mature spermatids for release into the tubular lumen. Just prior to spermiation, the elongated spermatid interacts with the Sertoli cell via an extensive structure comprising various adhesion molecules called the apical ectoplasmic specialization which is partially replaced by the apical TBC, on the concave surface of the spermatid head. The sperm release process involves extensive restructuring, namely the disassembly and reassembly of junctions at the Sertoli–spermatid interface in the seminiferous epithelium. Based on the presence of different classes of molecules in the TBCs or the defects observed in the absence of TBCs, the main functions attributed to TBCs are elimination of excess spermatid cytoplasm, endocytosis and recycling of junctional molecules, shaping of the spermatid acrosome, and forming transient anchoring devices for mature spermatids before they are released. This review summarizes the recent findings that focus on the role of TBCs in cell cytoskeleton restructuring during sperm release in the testes and the molecular mechanism involved.
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影响因子：
3.6
作者：
Guttman, JA;Takai, Y;Vogl, AW
通讯作者：
Vogl, AW
影响因子：
2.1
作者：
Inagaki, Maiko;Irie, Kenji;Takai, Yoshimi
通讯作者：
Takai, Yoshimi
影响因子：
3.6
作者：
MUFFLY, KE;NAZIAN, SJ;CAMERON, DF
通讯作者：
CAMERON, DF
影响因子：
4
作者：
Obermann, H;Raabe, I;Kirchhoff, C
通讯作者：
Kirchhoff, C
DOI：
10.1083/jcb.200904054
发表时间：
2009-11-30
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ezratty EJ;Bertaux C;Marcantonio EE;Gundersen GG
通讯作者：
Gundersen GG