Comparison of oxyhemoglobin and deoxyhemoglobin signal reliability with and without global mean removal for digit manipulation motor tasks.
Comparison of oxyhemoglobin and deoxyhemoglobin signal reliability with and without global mean removal for digit manipulation motor tasks.
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DOI：
10.1117/1.nph.5.1.011006
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发表时间：
2018-01
期刊：
影响因子：
5.3
通讯作者：
Hirsch J
中科院分区：
文献类型：
--
作者：
Dravida S;Noah JA;Zhang X;Hirsch J
功能性近红外光谱（fNIRS）可能非常适合临床使用，例如测量治疗前后的神经活动;但是，必须确保fNIRS信号的可靠性和特异性，以便将差异归因于干预。本研究比较了空间滤波前后氧合血红蛋白和脱氧血红蛋白信号的重测信度和纵向信度。在重测实验中，14名参与者在两天内进行了扫描，同时执行四个右手手指操作任务。组的结果显示，氧合血红蛋白的重测信度比脱氧血红蛋白信号和更大的空间特异性的脱氧血红蛋白信号。为了进一步表征可靠性，进行了一项纵向实验，其中两名参与者重复相同的运动任务10天。分别在空间滤波脱氧血红蛋白信号中具有最低和最高重测信度的两个任务的β值被报告为代表性结果。重测法和纵向法均证实了任务和信号类型对信度的影响。氧合血红蛋白信号总体上比脱氧血红蛋白更可靠，并且去除全局平均值降低了两种信号的可靠性。研究结果与以下建议一致：氧合血红蛋白信号中最常见的全身成分可能会相对于脱氧血红蛋白信号而增加可靠性，而脱氧血红蛋白信号受全身因素影响较小。
Functional near-infrared spectroscopy (fNIRS) could be well suited for clinical use, such as measuring neural activity before and after treatment; however, reliability and specificity of fNIRS signals must be ensured so that differences can be attributed to the intervention. This study compared the test–retest and longitudinal reliability of oxyhemoglobin and deoxyhemoglobin signals before and after spatial filtering. In the test–retest experiment, 14 participants were scanned on 2 days while performing four right-handed digit-manipulation tasks. Group results revealed greater test–retest reliability for oxyhemoglobin than deoxyhemoglobin signals and greater spatial specificity for the deoxyhemoglobin signals. To further characterize reliability, a longitudinal experiment was conducted in which two participants repeated the same motor tasks for 10 days. Beta values from the two tasks with the lowest and highest test–retest reliability, respectively, in the spatially filtered deoxyhemoglobin signal are reported as representative findings. Both test–retest and longitudinal methods confirmed that task and signal type influence reliability. Oxyhemoglobin signals were more reliable overall than deoxyhemoglobin, and removal of the global mean reduced reliability of both signals. Findings are consistent with the suggestion that systemic components most prevalent in the oxyhemoglobin signal may inflate reliability relative to the deoxyhemoglobin signal, which is less influenced by systemic factors.