NTS and VTA oxytocin reduces food motivation and food seeking.
NTS and VTA oxytocin reduces food motivation and food seeking.
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NTS 和 VTA 催产素会降低食物动机和食物寻找。
DOI：
10.1152/ajpregu.00201.2020
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Grill,HarveyJ
中科院分区：
文献类型：
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作者：
Wald,HallieS;Chandra,Ananya;Kalluri,Anita;Ong,ZhiYi;Hayes,MatthewR;Grill,HarveyJ
催产素（OT）是一种神经肽，其中枢受体介导的作用包括减少食物摄入。其行为学作用机制之一是放大由后脑神经元处理的胃肠道（GI）饱足信号的摄食抑制作用。OT治疗还减少了人类和啮齿动物的碳水化合物摄入，相应地，中枢OT受体（OT-R）信号传导的缺陷增加了蔗糖自我给药。这表明，额外的过程有助于中央OT对摄食的影响。本研究探讨了中枢OT通过减少食物寻求和食物动机来减少食物摄入的假设。由于中央OT-R广泛表达，相关的焦点是评估一个或多个OT-R表达核在食物动机和寻食行为中的作用。OT被传递到侧脑室（LV），孤束核（NTS），或腹侧被盖区（VTA），和一个渐进的比例（PR）的时间表的操作性强化和操作性恢复范式被用来测量动机性摄食行为和觅食行为，分别。将OT传递到LV、NTS或VTA降低了1）为食物而工作的动机和2）寻找食物行为的恢复。结果提供了一个新的和额外的解释，中央OT驱动的食物摄入抑制，包括减少食物的动机和食物寻求。
Oxytocin (OT) is a neuropeptide whose central receptor-mediated actions include reducing food intake. One mechanism of its behavioral action is the amplification of the feeding inhibitory effects of gastrointestinal (GI) satiation signals processed by hindbrain neurons. OT treatment also reduces carbohydrate intake in humans and rodents, and correspondingly, deficits in central OT receptor (OT-R) signaling increase sucrose self-administration. This suggests that additional processes contribute to central OT effects on feeding. This study investigated the hypothesis that central OT reduces food intake by decreasing food seeking and food motivation. As central OT-Rs are expressed widely, a related focus was to assess the role of one or more OT-R-expressing nuclei in food motivation and food-seeking behavior. OT was delivered to the lateral ventricle (LV), nucleus tractus solitarius (NTS), or ventral tegmental area (VTA), and a progressive ratio (PR) schedule of operant reinforcement and an operant reinstatement paradigm were used to measure motivated feeding behavior and food-seeking behavior, respectively. OT delivered to the LV, NTS, or VTA reduced1) motivation to work for food and2) reinstatement of food-seeking behavior. Results provide a novel and additional interpretation for central OT-driven food intake inhibition to include the reduction of food motivation and food seeking.