Quality of life in patients with intermittent claudication.
Quality of life in patients with intermittent claudication.
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DOI：
10.1007/s00772-017-0269-4
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Chetter IC
中科院分区：
文献类型：
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作者：
Harwood AE;Totty JP;Broadbent E;Smith GE;Chetter IC
间歇性跛行（IC）是一种常见的疾病，在行走时会导致下肢疼痛，并已被证明会严重影响患者的生活质量（QoL）。因此，在间歇性跛行的临床研究中，生活质量通常被视为一项重要指标。到目前为止，对于所使用的生活调查表的类型还没有达成共识。本综述的目的是检查生活质量问卷调查外周动脉疾病（PAD）的试验中使用。对随机临床试验进行了系统综述，包括通过问卷进行的QoL主要分析。纳入了涉及确诊PAD患者的试验（临床或问卷调查）。任何以QoL作为主要结局数据的试验均纳入，对所用问卷类型没有限制。检索共获得1845篇文章，其中31篇被认为适合纳入综述。在31项研究中，共使用了14份不同的QoL问卷。24.06%的问卷在研究结果中报告时至少缺失一个领域。平均标准差根据报告的领域有很大差异，特别是在SF 36内。尽管以前的欧洲生活质量评估标准化的建议，到目前为止还没有这样的工具存在。这项审查表明，一些不同的问卷仍在使用，他们的完成往往是不够的，需要进一步的循证指南生活质量评估，以指导未来的研究。
Intermittent claudication (IC) is a common condition that causes pain in the lower limbs when walking and has been shown to severely impact the quality of life (QoL) of patients. The QoL is therefore often regarded as an important measure in clinical trials investigating intermittent claudication. To date, no consensus exits on the type of life questionnaire to be used. This review aims to examine the QoL questionnaires used in trials investigating peripheral arterial disease (PAD). A systematic review of randomised clinical trials including a primary analysis of QoL via questionnaire was performed. Trials involving patients with diagnosed PAD were included (either clinically or by questionnaire). Any trial which had QoL as the primary outcome data was included with no limit being placed on the type of questionnaire used. The search yielded a total of 1845 articles of which 31 were deemed appropriate for inclusion in the review. In total, 14 different QoL questionnaires were used across 31 studies. Of the questionnaires 24.06% were missing at least one domain when reported in the results of the study. Mean standard deviation varied widely based on the domain reported, particularly within the SF36. Despite previous recommendations for Europewide standardisation of quality of life assessment, to date no such tool exists. This review demonstrated that a number of different questionnaires remain in use, that their completion is often inadequate and that further evidence-based guidelines on QoL assessment are required to guide future research.