Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese
Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese
复制标题
脂质代谢将超重或肥胖男性的营养运动时间与胰岛素敏感性联系起来
DOI：
10.1101/742627
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Edinburgh R
中科院分区：
文献类型：
--
作者：
Edinburgh R
目的研究运动前和运动后营养素摄入对全身和肌内脂肪利用率及餐后葡萄糖代谢的急性和慢性影响。设计（1）急性、随机、交叉设计（急性研究）;（2）6周、随机、对照设计（培训研究）.设置一般社区.紧身裤超重/肥胖男性（平均值±标准差，体重指数：急性研究为30.2 ± 3.5 kg/cm-2，30.9 ± 4.5 kg/cm-2（训练研究）。干预措施在混合宏量营养素早餐前后进行中等强度的自行车运动（急性研究）或碳水化合物结果急性研究运动前与早餐后消费增加净肌内脂质利用的I型糖尿病患者（净变化：-3.44 ± 2.63%对1.44 ± 4.18%面积脂质染色，P< 0.01）和II型纤维（-1.89 ± 2.48%对1.83 ± 1.92%面积脂质染色，P< 0.05）。训练研究-餐后血糖在6周运动训练前和6周运动训练后对碳水化合物摄入量的影响无显著性差异（P> 0.05）。然而，餐后胰岛素血症减少运动训练之前，但不是碳水化合物摄入后（P= 0.03）。这导致口服葡萄糖胰岛素敏感性增加（25 ± 38 vs-21 ± 32 mL·min-1·m-2;P= 0.01），与运动期间脂质利用增加相关（r= 0.50，P = 0.02）。营养供应前的定期运动也增加了骨骼肌磷脂和葡萄糖转运蛋白GLUT 4蛋白含量的重塑（P< 0.05）。结论调查运动训练和代谢健康的实验应考虑营养-运动时机，营养摄入前与营养摄入后（即禁食状态）进行的运动可能对脂质利用产生有益影响，并减少餐后胰岛素血症。
ContextPre-exercise nutrient availability alters acute metabolic responses to exercise, which could modulate training responsiveness.ObjectiveTo assess acute and chronic effects of exercise performed before versusafter nutrient ingestion on whole-body and intramuscular lipid utilization and postprandial glucose metabolism.Design(1) Acute, randomized, crossover design (Acute Study); (2) 6-week, randomized, controlled design (Training Study).SettingGeneral community.ParticipantsMen with overweight/obesity (mean ± standard deviation, body mass index: 30.2 ± 3.5 kg⋅m-2for Acute Study, 30.9 ± 4.5 kg⋅m-2for Training Study).InterventionsModerate-intensity cycling performed before versus after mixed-macronutrient breakfast (Acute Study) or carbohydrate (Training Study) ingestion.ResultsAcute Study—exercise before versus after breakfast consumption increased net intramuscular lipid utilization in type I (net change: –3.44 ± 2.63% versus 1.44 ± 4.18% area lipid staining,P< 0.01) and type II fibers (–1.89 ± 2.48% versus 1.83 ± 1.92% area lipid staining,P< 0.05). Training Study—postprandial glycemia was not differentially affected by 6 weeks of exercise training performed before versus after carbohydrate intake (P> 0.05). However, postprandial insulinemia was reduced with exercise training performed before but not after carbohydrate ingestion (P= 0.03). This resulted in increased oral glucose insulin sensitivity (25 ± 38 vs –21 ± 32 mL⋅min-1⋅m-2;P= 0.01), associated with increased lipid utilization during exercise (r= 0.50,P= 0.02). Regular exercise before nutrient provision also augmented remodeling of skeletal muscle phospholipids and protein content of the glucose transport protein GLUT4 (P< 0.05).ConclusionsExperiments investigating exercise training and metabolic health should consider nutrient-exercise timing, and exercise performed before versus after nutrient intake (ie, in the fasted state) may exert beneficial effects on lipid utilization and reduce postprandial insulinemia.