Sleep disturbances in depressed and nondepressed pregnant women.
Sleep disturbances in depressed and nondepressed pregnant women.
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DOI：
10.1002/da.20828
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发表时间：
2011-08
影响因子：
7.4
通讯作者：
Wisner, Katherine L.
中科院分区：
文献类型：
--
作者：
Okun, Michele L.;Kiewra, Kerith;Luther, James F.;Wisniewski, Stephen R.;Wisner, Katherine L.
睡眠障碍和抑郁症状在怀孕期间很常见。两者都是不良结局的独立和相互关联的风险因素。目前还不清楚抑郁症和非抑郁症孕妇的睡眠差异程度。我们试图1）描述和比较抑郁症孕妇和非抑郁症孕妇的睡眠障碍，2）确定选择性5-羟色胺再摄取抑制剂（SSRI）治疗对睡眠的影响，3）评估20周的睡眠是否与妊娠后期抑郁症状增加和重度抑郁症（MDD）相关。在妊娠中期（妊娠20周）招募孕妇（N = 240），并根据严重抑郁症的SCID诊断将其分为抑郁组（N = 59）和非抑郁组（N = 181）。在妊娠20、30和36周时使用汉密尔顿评定量表与非典型抑郁补充剂（SIGH-ADS）的结构化访谈指南，从中获得睡眠变量。抑郁女性在每次评估时的睡眠碎片更多（p值≤ .05）。然而，只有在怀孕20周时，抑郁症女性的失眠症状频率才更高。SSRI的使用，无论MDD状态如何，都显著影响了几个睡眠变量。在非抑郁症女性中，睡眠时间短或较长、有失眠症状和夜间觉醒时间长的女性在怀孕后期的SIGH-ADS评分较高（p值= < .05）。在妊娠20周和30周时，抑郁症孕妇的睡眠比非抑郁症孕妇更受干扰。在36周时，无论抑郁状态或SSRI使用情况如何，睡眠都受到干扰。在非抑郁的女性中，睡眠障碍与SSRI的使用与更高的抑郁症状有关。
Sleep disturbances and symptoms of depression are common during pregnancy. Both are independent and interrelated risk factors for adverse outcomes. It is unclear the degree to which sleep differs between depressed and non-depressed pregnant women. We sought to 1), describe and compare sleep disturbances in depressed pregnant and non-depressed pregnant women, 2) determine the impact of selective serotonin reuptake inhibitors (SSRI) treatment on sleep, and 3)evaluate whether sleep at 20 weeks is associated with increased depressive symptoms and major depressive disorder (MDD) in later pregnancy. Pregnant women (N = 240) were recruited in the second trimester (20 weeks gestation) and assigned to depressed (N = 59) and non-depressed (N = 181) groups based on a SCID diagnosis of major depressive disorder. The Structured Interview Guide for the Hamilton Rating Scale with Atypical Depression Supplement (SIGH-ADS) was administered at 20, 30 and 36 weeks gestation from which the sleep variables were obtained. Depressed women had more fragmented sleep at each assessment (p values ≤ .05). However, the frequency of insomnia symptoms was greater for depressed women only at 20 weeks gestation. SSRI use, regardless of MDD status, did significantly affect several sleep variables. Among the non-depressed women, those with short or longer sleep duration, symptoms of insomnia and long periods of nocturnal waketime had higher SIGH-ADS scores later in pregnancy (p values = < .05). At 20 and 30 weeks gestation sleep was more disturbed in depressed pregnant women compared to non-depressed pregnant women. At 36 weeks, sleep was disturbed regardless of depression status or SSRI use. Among the non-depressed women, disturbed sleep in conjunction with SSRI use was associated with higher depressive symptoms.
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影响因子：
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作者：
Grote, Nancy K.;Bridge, Jeffrey A.;Gavin, Amelia R.;Melville, Jennifer L.;Iyengar, Satish;Katon, Wayne J.
通讯作者：
Katon, Wayne J.
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通讯作者：
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