ISOLATION OF A T-LYMPHOTROPIC RETROVIRUS FROM A PATIENT AT RISK FOR ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS)
ISOLATION OF A T-LYMPHOTROPIC RETROVIRUS FROM A PATIENT AT RISK FOR ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS)
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DOI：
10.1126/science.6189183
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
MONTAGNIER, L
中科院分区：
文献类型：
--
作者：
BARRESINOUSSI, F;CHERMANN, JC;MONTAGNIER, L
一种逆转录病毒属于最近发现的人类T细胞白血病病毒（HTLV）家族，但与以前的每种分离株都有明显区别，该病毒是从一名白人患者中分离出来的，该患者的体征和症状通常先于获得性免疫缺陷综合征（AIDS）。该病毒是典型的C型RNA肿瘤病毒，从细胞膜出芽，偏好Mg的逆转录酶活性，并具有与HTLV p24相似的内部抗原（p25）。来自该患者血清的抗体与来自HTLV-I亚组的病毒的蛋白质反应，但HTLV-I的类型特异性抗血清不沉淀新分离物的蛋白质。该患者的病毒被传播到脐带血淋巴细胞中;这些细胞产生的病毒与原始分离株相似。这种病毒和以前的HTLV分离株显然属于T淋巴细胞嗜性逆转录病毒的一个大家族，在人类中水平传播，并可能涉及几种病理综合征，包括艾滋病。
A retrovirus belonging to the family of recently discovered human T-cell leukemia viruses (HTLV), but clearly distinct from each previous isolate, was isolated from a Caucasian patient with signs and symptoms that often precede the acquired immune deficiency syndrome (AIDS). This virus is a typical type-C RNA tumor virus, buds from the cell membrane, prefers Mg for reverse transcriptase activity and has an internal antigen (p25) similar to HTLV p24. Antibodies from serum of this patient react with proteins from viruses of the HTLV-I subgroup, but type-specific antisera to HTLV-I do not precipitate proteins of the new isolate. The virus from this patient was transmitted into cord blood lymphocytes; the virus produced by these cells is similar to the original isolate. This virus and the previous HTLV isolates evidently belong to a general family of T-lymphotropic retroviruses that are horizontally transmitted in humans and may be involved in several pathological syndromes, including AIDS.