Synthesis of optically active 3-alkoxy-6-hydroxymethyl-6-methyl-2-cyclohexenone
Synthesis of optically active 3-alkoxy-6-hydroxymethyl-6-methyl-2-cyclohexenone
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DOI：
10.1016/s0957-4166(99)00304-3
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发表时间：
1999-08-13
影响因子：
--
通讯作者：
Yamada, Y
中科院分区：
文献类型：
--
作者：
Miyaoka, H;Kajiwara, Y;Yamada, Y
通过脂肪酶催化的动力学拆分，得到了具有光学活性的3-烷氧基-6-羟甲基-6-甲基-2-环己烯酮和6-乙酰氧基甲基-3-烷氧基-6-甲基-2-环己烯酮。(R)-6-乙酰氧基甲基-3-（甲氧基甲氧基）-6-甲基-2-环己酮转化为木耳醇合成中间体。1999爱思唯尔科学有限公司版权所有。
Optically active 3-alkoxy-6-hydroxymethyl-6-methyl-2-cyclohexenone and 6-acetoxymethyl-3-alkoxy-6-methyl-2-cyclohexenone were efficiently obtained by lipase-catalyzed kinetic resolution. (R)-6-Acetoxymethyl-3-(methoxymethoxy)-6-methyl-2-cyclohexenone was converted to the synthetic intermediate of cassiol. (C) 1999 Elsevier Science Ltd. All rights reserved.