The effect of indomethacin on alveolar bone loss in experimental periodontitis.
The effect of indomethacin on alveolar bone loss in experimental periodontitis.
复制标题
吲哚美辛对实验性牙周炎牙槽骨丢失的影响。
DOI：
10.1111/j.1600-0765.1982.tb01134.x
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发表时间：
1982
影响因子：
3.5
通讯作者：
Rifkin,BR
中科院分区：
文献类型：
--
作者：
Weaks-Dybvig,M;Sanavi,F;Zander,H;Rifkin,BR
这项研究是为了确定前列腺素是否在牙周炎结扎模型中导致骨丢失的事件中起作用。在松鼠猴（samiri sciureus）的一侧下颌牙齿周围放置结扎物可引起牙周炎。从结扎放置的前一天开始，一半的动物服用吲哚美辛（5mg /kg/天），这是一种有效的前列腺素合成抑制剂。实验牙周炎1周和2周后处死动物。研究发现，吲哚美辛治疗消除了未使用吲哚美辛治疗（NIT）的动物在结扎后牙槽骨高度和骨量的显著损失。吲哚美辛还抑制了NIT动物在一周内测量的破骨细胞密度的大幅增加。结果支持前列腺素是牙周炎结扎模型中骨质流失的重要介质的假设。也有证据表明，在牙周韧带和骨内膜表面，骨吸收与成骨细胞新生骨形成相互耦合。
This study was undertaken to determine if prostaglandins play a role in the events leading to loss of bone in the ligature model of periodontitis. Periodontitis was induced by placement of the ligatures around mandibular teeth on one side of the jaw of squirrel monkeys (Saimiri sciureus). From one day prior to ligature placement, half the animals were administered indomethacin (5 mg/kg/day), a potent inhibitor of prostaglandin synthesis. Animals were sacrificed after one and two weeks of experimental periodontitis. It was found that indomethacin treatment abolished the significant losses of alveolar bone height and bone mass seen in non‐indomethacin‐treated (NIT) animals following ligature placement. Indomethacin also depressed the large increase in osteoclast density measured at one week in the NIT animals. The results support the hypothesis that prostaglandins are an important mediator of bone loss in the ligature model of periodontitis. Evidence is also presented for the coupling of bone resorption with osteoblastic neo‐osteogenesis on both periodontal ligament and endosteal bone surfaces.