Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis
Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis
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DOI：
10.1073/pnas.0409766102
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发表时间：
2005-03-01
影响因子：
11.1
通讯作者：
Tallerico, T
中科院分区：
文献类型：
--
作者：
Seeman, P;Weinshenker, D;Tallerico, T
多巴胺超敏性发生在精神分裂症和其他精神病中，以及海马损伤后，抗精神病药，乙醇，安非他明，苯环己哌啶，Dbh（多巴胺β-羟化酶），Drd 4受体，Gprk 6（G蛋白偶联受体激酶6），Comt（儿茶酚-O-甲基转移酶）或Th-/-，Dbh（Th/+）（酪氨酸羟化酶）的基因敲除，以及剖腹产出生的大鼠中。D2的功能状态，或多巴胺的高亲和力状态（D2（高）），在这些超敏感的动物脑纹状体中测量。在所有这些组织中均发现D2（高）水平升高和比例较高（40-900%）。如果许多类型的脑损伤导致多巴胺行为超敏和D2（高）状态的普遍增加，这表明精神病有许多途径，其中任何一个都可以被破坏。
Dopamine supersensitivity occurs in schizophrenia and other psychoses, and after hippocampal lesions, antipsychotics, ethanol, amphetamine, phencyclidine, gene knockouts of Dbh (dopamine beta-hydroxylase), Drd4 receptors, Gprk6 (G protein-coupled receptor kinase 6), Comt (catechol-O-methyltransferase), or Th-/-, Dbh(Th/+) (tyrosine hydroxylase), and in rats born by Cesarean-section. The functional state of D2, or the high-affinity state for dopamine (D2(High)), was measured in these supersensitive animal brain striata. Increased levels and higher proportions (40-900%) for D2(High) were found in all these tissues. If many types of brain impairment cause dopamine behavioral supersensitivity and a common increase in D2(High) states, it suggests that there are many pathways to psychosis, any one of which can be disrupted.