Signalling pathways implicated in the pathogenesis of rheumatic heart disease (Review).
Signalling pathways implicated in the pathogenesis of rheumatic heart disease (Review).
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DOI：
10.3892/etm.2020.9508
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发表时间：
2021-01
影响因子：
2.7
通讯作者：
Zeng Z
中科院分区：
文献类型：
--
作者：
Xian S;Zeng Z
风湿性心脏病（RHD）在欠发达地区常见，主要影响40岁以下的患者。风湿性心脏病的发病机制尚未完全阐明，手术治疗仍然是唯一的选择，这是昂贵的，技术要求不发达地区的患者。信号通路对多种疾病的发生和发展至关重要，世界各地的研究人员在阐明与RHD发病机制相关的信号通路方面取得了进展。本文就与风湿性心脏病发病相关的6条信号通路进行综述，总结其研究方法和进展，并提出今后的研究方向。根据目前信号通路的研究进展，对风心病发病机制的重要信息进行了综述，以期为风心病发病机制中信号通路的研究提供参考。
Rheumatic heart disease (RHD) is frequently encountered in underdeveloped areas and primarily affects patients under the age of 40 years old. The pathogenesis of RHD has yet to be fully elucidated and surgical treatment remains the only option, which is expensive and technically demanding for patients in less developed areas. Signalling pathways are crucial for the occurrence and development of several diseases, and researchers worldwide have made progress in elucidating the signalling pathways associated with the pathogenesis of RHD. The aim of the present review was to discuss 6 signalling pathways implicated in the pathogenesis of RHD, summarize the methods and progress of these studies and propose future research directions. Important information on the pathogenesis of RHD according to the current progress of signalling pathway studies was also summarized, in the hope that this review may serve as a reference for future research on the signalling pathways involved in the pathogenesis of RHD.
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