Homologous desensitization of the effects of endothelin on rabbit aorta rings and on cultured rat aorta smooth muscle cells.
Homologous desensitization of the effects of endothelin on rabbit aorta rings and on cultured rat aorta smooth muscle cells.
复制标题
内皮素对兔主动脉环和培养的大鼠主动脉平滑肌细胞影响的同源脱敏。
DOI：
10.1016/0014-2999(90)90412-y
复制
发表时间：
1990
影响因子：
5
通讯作者：
A. Paiva
中科院分区：
文献类型：
--
作者：
N. Miasiro;A. Paiva
本文观察了内皮素-1对正常和外翻兔主动脉环及培养的大鼠主动脉平滑肌细胞的作用。内皮素-1（40 nM）使正常和翻转的环收缩，并且在无Ca 2+培养基中仍然能够诱导延长的收缩。用100 nM内皮素-1处理培养的细胞引起45 Ca 2+流出的急剧瞬时增加。收缩反应和45 Ca ~（2+）反应对内皮素-1表现出严重的特异性脱敏，而对血管紧张素II和肾上腺素的反应不受影响。对内皮素-1的收缩反应不受既往血管紧张素II或血管紧张素受体拮抗剂[Sar 1，Ala 8]血管紧张素II治疗的影响。结论是内皮素-1作用于其自身的特异性受体，引起细胞内和细胞外来源的Ca 2+动员。
The effects of endothelin-1 on normal and everted rabbit aorta rings and on cultured rat aortic smooth muscle cells were studied. Endothelin-1 (40 nM) contracted both normal and everted rings, and was still able to induce a prolonged contraction in Ca2+-free medium. Treatment of cultured cells with 100 nM endothelin-1 caused a sharp transient increase in45Ca2+efflux. The contractile and45Ca2+responses showed severe and specific desensitization towards endothelin-1; the responses to angiotensin II and adrenaline were not affected. The contractile responses to endothelin-1 were not affected by previous treatment with angiotensin II or with the angiotensin receptor antagonist, [Sar1,Ala8]angiotensin II. It is concluded that endothelin-1 acts on its own specific receptors to elicit Ca2+mobilization from both intracellular and extracellular sources.
地尔硫卓抑制血管平滑肌收缩力的机制。
DOI：
--
发表时间：
1981
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
vanBreemen,C;Hwang,O;Meisheri,KD
通讯作者：
Meisheri,KD