Cardiovascular response to graded exercise in the sympathectomized-vagotomized dog.
Cardiovascular response to graded exercise in the sympathectomized-vagotomized dog.
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交感神经切除和迷走神经切断的狗对分级运动的心血管反应。
DOI：
10.1152/ajplegacy.1963.204.2.291
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发表时间：
1963
期刊：
影响因子：
--
通讯作者：
W. Hamilton
中科院分区：
文献类型：
--
作者：
E. Ashkar;W. Hamilton
7只在电动跑步机上跑得很好的狗被完全切除交感神经（包括肾上腺去神经），并在喉返分支下方进行单侧迷走神经切断术。在恢复和再训练后，进行终末实验，其中在完成迷走神经切断术后，在休息和增加运动期间进行心输出量的直接Fick测定和平均动脉压、心率和氧消耗的连续记录。184：613，1956）的正常狗运行在较小的速度和等级。手术犬的心率从117增加到134。巴格的正常狗的心率增加了一倍。A-V氧差随着工作的增加而增加，略低于Barger的正常犬，但两组的离散度很大，每搏输出量也是如此。手术犬的静息心输出量几乎正常，但运动后仅增加34%，而Barger正常犬则增加200-300%。氧气消耗量增加了大约两倍，而预期的正常值是三到七倍。两组的外周阻力都下降了约40%。正常犬血压明显升高，而手术犬血压下降约20%，平均为60 mm Hg。
Seven dogs who ran well on a motor-driven treadmill were completely sympathectomized (including adrenal denervation) and subjected to unilateral vagotomy below the recurrent laryngeal branch. After recovery and retraining, a terminal experiment was performed in which, after completing the vagotomy, direct Fick determinations of cardiac output and continuous recordings of mean arterial pressure, heart rate, and oxygen consumption were made at rest and during increasing exercise The results were compared with those described by Barger et al. ( Am. J. Physiol. 184: 613, 1956) for normal dogs running at smaller speeds and grades. The heart rate of the operated dogs increased from 117 to 134. Barger's normal dogs doubled their heart rate. The A-V oxygen difference increased with work slightly less than Barger's normal dogs but the scatter in both groups was wide, as was the case with the stroke volume. The resting cardiac output was nearly normal in the operated dogs but increased only 34% with exercise, as against 200–300% in Barger's normals. Oxygen consumption increased about twofold as against the expected normal of three- to sevenfold. Peripheral resistance in both groups went down about 40%. The blood pressure in the normal increased substantially while that in the operated dogs fell about 20% to an average of 60 mm Hg.