Essential and aging‐related tremor: Differences of central control
Essential and aging‐related tremor: Differences of central control
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原发性震颤和衰老相关震颤：中枢控制的差异
DOI：
10.1002/mds.26410
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发表时间：
2015
影响因子：
8.6
通讯作者：
S.A. Schneider
中科院分区：
文献类型：
--
作者：
M. Muthuraman;G. Deuschl;A.R. Anwar;K.G. Mideksa;F. von Helmolt;S.A. Schneider
背景原发性震颤的发病年龄呈双峰分布，高峰在青春期，另一个在成年晚期。后者在这里被称为与衰老相关的震颤，它被认为与早期衰老和死亡率增加有关。我们假设，不同的震颤网络检测到的多通道脑电图（EEG）的基础这两个tremor groups.MethodsWe调查了20例原发性震颤分为两组和10个年龄和性别匹配的年龄相关的震颤患者使用池的最大相干EEG电极的相干频谱在举行的任务，捏握任务，同时进行缓慢的手部运动。功能和有效的连接在耦合frequencyestimated.ResultsThe最大的连贯性是显着更高的早发性特发性震颤相比，在这三个任务与老化相关的震颤。与年龄相关性震颤患者相比，2 Hz至40 Hz功率、频谱峰值频率和相对信噪比无差异，但特发性震颤的肌电振幅显著更大。源分析显示了经典特发性震颤的众所周知的皮质-脑干-小脑-丘脑-皮质网络，但衰老相关震颤患者仅显示皮质-丘脑网络。两次震颤的震源之间的连接是双向的。只有小脑和脑干在原发性震颤和丘脑中显示出单向连接。第二个特发性震颤组具有相似的肌电图振幅证实了这两种震颤type.ConclusionWe之间的差异表明，振荡的大脑网络基础的经典特发性震颤和衰老相关的震颤不同，这表明一个病理生理差异。© 2015国际帕金森和运动障碍协会
BackgroundFor essential tremor, the distribution of age of onset is bimodally distributed, with peaks in adolescence and another in late adulthood. The latter is here referred to as aging‐related tremor, and it is considered to be associated with earlier aging and increased mortality. We hypothesize that different tremor networks detected by multichannel electroencephalography (EEG) underlie these two tremor groups.MethodsWe investigated 20 patients with essential tremor separated into two groups and 10 age‐ and sex‐matched aging‐related tremor patients using pooled coherence spectra of the maximally coherent EEG electrodes during a holding task, a pinch grip task, and whilst performing slow hand movements. Functional and effective connectivity at the coupling frequency was estimated.ResultsThe maximal coherence was significantly higher in early‐onset essential tremor compared with aging‐related tremor during the three tasks. Compared with the patients with aging‐related tremor, 2 Hz to 40 Hz power, spectral peak frequency, and relative signal‐to‐noise ratio were not different, but the electromyographic amplitude was significantly greater in essential tremor. The source analysis revealed the well‐known cortico‐brainstem‐cerebello‐thalamo‐cortical network for classical essential tremor, but patients with aging‐related tremor showed a cortico‐thalamic network only. The connections between the sources for both tremors were bidirectional. Only the cerebellum and the brainstem showed unidirectional connections in essential tremor and the thalamus in aging‐related tremor patients. A second essential tremor group with similar electromyographic amplitudes confirmed the differences between both tremor types.ConclusionWe show that the oscillating cerebral networks underlying classical essential tremor and aging‐related tremor differ, suggesting a pathophysiological difference. © 2015 International Parkinson and Movement Disorder Society
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影响因子：
3.5
作者：
Zhi Zhang
通讯作者：
Zhi Zhang
影响因子：
6.8
作者：
AKAIKE, H
通讯作者：
AKAIKE, H
影响因子：
8.6
作者：
J. Raethjen;M. Muthuraman;Achim Kostka;Martin Nahrwold;H. Hellriegel;D. Lorenz;G. Deuschl
通讯作者：
J. Raethjen;M. Muthuraman;Achim Kostka;Martin Nahrwold;H. Hellriegel;D. Lorenz;G. Deuschl
老年人的手部肌肉在等长收缩期间运动单位的一致性更强。
DOI：
10.1152/jn.00941.2002
发表时间：
2003
期刊：
Journal of neurophysiology.
影响因子：
--
作者：
Semmler,JohnG;Kornatz,KurtW;Enoka,RogerM
通讯作者：
Enoka,RogerM
影响因子：
4.7
作者：
M. Muthuraman;R. Govindan;G. Deuschl;U. Heute;J. Raethjen
通讯作者：
J. Raethjen