Impaired nephrogenesis in neonatal rats with oxygen-induced retinopathy.
Impaired nephrogenesis in neonatal rats with oxygen-induced retinopathy.
复制标题
氧诱导性视网膜病变新生大鼠肾发生受损。
DOI：
10.1111/ped.13264
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发表时间：
2017
影响因子：
1.4
通讯作者：
Shimizu T.
中科院分区：
文献类型：
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作者：
Nakagawa M;Nishizaki N;Endo A;Someya T;Saito Y;Mizutani A;Hara T;Murano Y;Sakuraya K;Hara S;Umino D;Hirano D;Fujinaga S;Ohtomo Y;Shimizu T.
目的：早产儿出生时正在进行肾发生，通常暴露于高氧环境中的因素，可能会损害肾脏发育。氧化应激也与早产儿视网膜病变（ROP）的发生有关。氧诱导视网膜病变（OIR）的大鼠模型是最具临床相关性的ROP模型，因为OIR的生物学特征与早产儿ROP的生物学特征非常相似。我们的目标是确定受损的
Objectives: Preterm neonates are born during ongoing nephrogenesis and are commonly exposed to factors in a hyperoxic environment that may impair renal development. Oxidative stress has also been implicated in the development of retinopathy of prematurity (ROP). The rat model of oxygen-induced retinopathy (OIR) is the most clinically relevant model of ROP because the biologic features of OIR closely resembles those of ROP in preterm infants. We aimed to determine impaired