Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis -: A longitudinal study
Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis -: A longitudinal study
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DOI：
10.1001/archneur.58.1.115
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发表时间：
2001-01-01
影响因子：
--
通讯作者：
Weiner, HL
中科院分区：
文献类型：
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作者：
Sperling, RA;Guttmann, CRG;Weiner, HL
目的：通过对多发性硬化症（MS）患者4年的随访，探讨磁共振成像区域病变负担与认知能力的关系。设计：28名多发性硬化症患者接受了磁共振成像，并在基线、1年和4年随访期间进行了简短、可重复的多发性硬化症神经心理测试。采用自动三维病变检测方法在质子密度t2加权图像上识别解剖区域内的MS病变。磁共振成像区域病变体积与多发性硬化症简短、可重复的神经心理测试结果之间的关系采用回归分析。结果：在各时间点，额叶病变体积占总病变体积的比例最大，额叶和顶叶白质病变的比例也最高。在神经心理测试中，与年龄和教育水平匹配的对照组相比，多发性硬化症患者在持续注意力、处理速度和言语记忆测试中表现出显著的损伤
Objective: To investigate the relationship between magnetic resonance imaging regional lesion burden and cognitive performance in multiple sclerosis (MS) over a 4-year follow-up period.Design: Twenty-eight patients with MS underwent magnetic resonance imaging and took the Brief, Repeatable Battery of Neuropsychological Tests in Multiple Sclerosis at baseline, 1-year, and 4-year follow-up. An automated 3-dimensional lesion detection method was used to identify MS lesions within anatomical regions on proton density T2-weighted images. The relationship between magnetic resonance imaging regional lesion volumes and the Brief, Repeatable Battery of Neuropsychological Tests in Multiple Sclerosis results was examined using regression analyses.Results: At all time points, frontal lesion volume represented the greatest proportion of total lesion volume, and the percentage of white matter classified as lesion was also highest in frontal and parietal regions. On neuropsychological testing, when compared with age- and educational level-matched control subjects, patients with MS showed significant impairment on tests of sustained attention, processing speed, and verbal memory (P