[Pharmacological study on citrus fruits. II. Anti-allergic effect of fruit of Citrus unshiu MARKOVICH (2). On flavonoid components].
[Pharmacological study on citrus fruits. II. Anti-allergic effect of fruit of Citrus unshiu MARKOVICH (2). On flavonoid components].
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柑橘类水果的药理研究。
DOI：
10.1248/yakushi1947.111.3_193
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
M. Mizuno
中科院分区：
文献类型：
--
作者：
H. Matsuda;M. Yano;M. Kubo;M. Iinuma;M. Oyama;M. Mizuno
进行了一项研究，以阐明柑橘温州MAKOVICH青果对I型过敏反应的活性成分。从其甲醇提取物中分离出的类黄酮成分橙皮苷，被发现可以抑制由化合物 48/80 诱导的大鼠腹膜肥大细胞释放组胺。口服橙皮苷可显着抑制完整大鼠的四十八小时同源被动皮肤过敏反应（PCA）。然而，在肾上腺切除的大鼠中未观察到 PCA 的抗过敏作用。这些结果表明橙皮苷是温州柑橘果实中的有效成分，具有针对I型反应的抗过敏作用。
A study was carried out to clarify the active component of green fruit of Citrus unshiu MAKOVICH on the type I allergic reaction. The flavonoid component, isolated from its methanolic extract, hesperidin, was found to inhibit histamine release from peritoneal mast cells of rats induced by compound 48/80. Forty eight-hour homologous passive cutaneous anaphylaxis (PCA) in intact rats was significantly inhibited by the oral administration of hesperidin. However, the anti-allergic action on PCA was not observed in adrenalectomized rats. These results suggests that hesperidin is an effective component of the fruit of Citrus unshiu with the anti-allergic action against the type I reaction.