Parameterizing cell movement when the instantaneous cell migration velocity is ill-defined
Parameterizing cell movement when the instantaneous cell migration velocity is ill-defined
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当瞬时细胞迁移速度不明确时参数化细胞运动
DOI：
10.1016/j.physa.2020.124493
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Almeida, R.
中科院分区：
文献类型：
--
作者：
Thomas, G.;Fortuna, I.;Perrone, G.;Glazier, J.;Belmone, J.;Almeida, R.
细胞爬行的特征通常是扩散常数D和瞬时速度|v→|2。然而，在实验上<；|v→|2>；有所不同。以D为参数的三区(扩散-弹道-扩散)修正的Fürth方程，无因次过剩扩散系数S和停留时间P与实验相符。S允许比较不同实验的轨迹，并对评估细胞运动所需的实验间隔和持续时间设置限制。已发表的各种实验中的细胞轨迹符合纵向朗之万动力学和横向维纳过程，S∼1+con S t a n t∗D−1。
Cell crawling has usually been characterized by a diffusion constant D and instantaneous velocity<| v→| 2>. However, experimentally<| v→| 2> diverges. A three regime (diffusive-ballistic-diffusive) modified Fürth equation parameterized by D, the dimensionless excess diffusion coefficient S and the persistence time P is compatible with experiment. S allows comparison of trajectories across experiments and sets limits on the intervals and duration of experiments required to assess cell movement. Cell trajectories in a variety of published experiments are consistent with longitudinal Langevin dynamics and a transverse Wiener process with S∼ 1+ c o n s t a n t∗ D− 1.