Smart electrospun nanofibers for controlled drug release: recent advances and new perspectives.
Smart electrospun nanofibers for controlled drug release: recent advances and new perspectives.
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DOI：
10.2174/1381612821666150302151959
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发表时间：
2015
影响因子：
3.1
通讯作者：
Xie J
中科院分区：
文献类型：
--
作者：
Weng L;Xie J
在生物系统中，化学分子或离子通常在特定条件下、在特定位置和在期望的时间段内释放。静电纺丝纳米纤维的物理化学特性随着环境的变化而发生变化，在各种应用中引起了人们的极大兴趣。受生物系统的启发，治疗分子已与这些智能电纺纳米纤维集成，呈现药物释放的激活调节或反馈调节控制。与智能水凝胶等其他材料相比，基于环境响应性纳米纤维的药物递送系统相对较新，但由于其更大的渗透性而具有无与伦比的优势，这使得响应时间更短，释放速率更精确。在这篇文章中，我们回顾了各种环境参数作为刺激的机制，以定制智能电纺纳米纤维的释放速率。我们还举例说明了几个典型的例子，在具体的应用。最后，我们讨论了这一领域的前景和未来的可能性。
In biological systems, chemical molecules or ions often release upon certain conditions, at a specific location, and over a desired period of time. Electrospun nanofibers that undergo alterations in the physicochemical characteristics corresponding to environmental changes have gained considerable interest for various applications. Inspired by biological systems, therapeutic molecules have been integrated with these smart electrospun nanofibers, presenting activation-modulated or feedback-regulated control of drug release. Compared to other materials like smart hydrogels, environment-responsive nanofiber-based drug delivery systems are relatively new but possess incomparable advantages due to their greater permeability, which allows shorter response time and more precise control over the release rate. In this article, we review the mechanisms of various environmental parameters functioning as stimuli to tailor the release rates of smart electrospun nanofibers. We also illustrate several typical examples in specific applications. We conclude this article with a discussion on perspectives and future possibilities in this field.