Metaplasia and somatic cell reprogramming
Metaplasia and somatic cell reprogramming
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DOI：
10.1002/path.2442
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发表时间：
2009-01
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影响因子：
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通讯作者：
J. Slack
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文献类型：
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作者：
J. Slack
现就化生的性质和发生作一简要综述。提出了一种关于化生是如何启动的理论，这取决于它代表了表达的发育转录因子组合的变化。本文介绍了两个由特定转录因子过度表达引起的实验性化生：B淋巴细胞向巨噬细胞的转化，以及胰腺外分泌细胞向肝细胞的转化。诱导多潜能干细胞(iPS细胞)的形成被认为是相同过程的一个例子，在这个过程中，目的状态是胚胎干细胞。值得注意的是，iPS细胞的生产是一个随机过程，取决于获得所需细胞类型的选择。建议使用类似的技术，使用适当的转录因子，可以转化为胚胎干细胞以外的其他类型的细胞。版权所有(C)2008大不列颠和爱尔兰病理学会。作者：John Wiley&Sons，Ltd.
The nature and occurrence of metaplasia is briefly reviewed. A theory of how metaplasia is initiated is presented, depending on the idea that it represents an alteration in the combination of developmental transcription factors that are expressed. Two examples of experimental metaplasia, provoked by over‐expression of specific transcription factors, are presented: the transformation of B lymphocytes to macrophages, and of pancreatic exocrine cells to hepatocytes. The formation of induced pluripotential stem cells (iPS cells) is considered an example of the same process, in which the destination state is the embryonic stem cell. It is noted that iPS cell production is a stochastic process, depending on selection to obtain the desired cell type. It is proposed that analogous technology, using the appropriate transcription factors, could be used to bring about transformation to cell types other than embryonic stem cells. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.