Structure elucidation of Sch 538415, a novel acyl carrier protein synthase inhibitor from a microorganism
Structure elucidation of Sch 538415, a novel acyl carrier protein synthase inhibitor from a microorganism
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DOI：
10.1016/j.bmcl.2003.07.011
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发表时间：
2003-11-03
影响因子：
2.7
通讯作者：
Gullo, V
中科院分区：
文献类型：
--
作者：
Chu, M;Mierzwa, R;Gullo, V
从一种未鉴定的细菌中分离到一种新的酰基载体蛋白合成酶抑制剂Sch 538415（1）。通过紫外光谱、质谱和核磁共振谱等波谱数据对化合物1进行了结构鉴定。化合物I在酰基载体蛋白合成酶（AcpS）测定中显示出抑制活性，IC 50值为4.19 μ M，并且在琼脂扩散测定中显示出对金黄色葡萄球菌的抗菌活性。(C)2003 Elsevier Ltd.保留所有权利。
A novel acyl carrier protein synthase inhibitor, Sch 538415 (1), was isolated from an unidentified bacterial microbe. Structure elucidation of 1 was accomplished based on analysis of spectroscopic data including UV, MS and 2D-NMR spectra. Compound I exhibited inhibitory activity in the acyl carrier protein synthase (AcpS) assay with an IC50 value of 4.19 muM and showed antibacterial activity against Staphylococcus aureus in the agar diffusion assay. (C) 2003 Elsevier Ltd. All rights reserved.