COLLAGENASE PRODUCTION BY RHEUMATOID SYNOVIAL CELLS - STIMULATION BY A HUMAN LYMPHOCYTE FACTOR
COLLAGENASE PRODUCTION BY RHEUMATOID SYNOVIAL CELLS - STIMULATION BY A HUMAN LYMPHOCYTE FACTOR
复制标题
DOI：
10.1126/science.188134
复制
发表时间：
1977-01-01
期刊：
影响因子：
56.9
通讯作者：
KRANE, SM
中科院分区：
文献类型：
--
作者：
DAYER, JM;RUSSELL, RGG;KRANE, SM
人外周血淋巴细胞在37 ℃培养1-3天。C，但不是在4.0度。C，释放一种可溶性因子，该因子可刺激分离的、粘附的类风湿性滑膜细胞产生高达400倍的胶原酶。植物血凝素或伴刀豆球蛋白A可增强淋巴细胞因子的产生。通过凝胶过滤，该因子具有约12，000的表观MW。
Human peripheral blood lymphocytes incubated in culture for 1-3 days at 37.degree. C, but not at 4.degree. C, release a soluble factor which can stimulate, up to 400-fold, collagenase production by isolated, adherent, rheumatoid synovial cells. Production of lymphocyte factor is enhanced by phytohemagglutinin or concanavalin A. By gel filtration, the factor has an apparent MW of about 12,000.