Highly Enantioselective [3+2]-Annulation of Isatin-Derived Morita-Baylis-Hillman Adducts with Cyclic Sulfonimines
Highly Enantioselective [3+2]-Annulation of Isatin-Derived Morita-Baylis-Hillman Adducts with Cyclic Sulfonimines
复制标题
靛红衍生的 Morita-Baylis-Hillman 加合物与环状磺胺的高度对映选择性 [3 2]-环化
DOI：
10.1021/acs.orglett.5b00456
复制
发表时间：
2015
期刊：
影响因子：
5.2
通讯作者：
Liu Li
中科院分区：
文献类型：
--
作者：
Wei Feng;Huang Hong-Yon;Zhong Neng-Jun;Gu Chun-Ling;Wang Dong;Liu Li
以烯丙基氮叶立德为中间体，以靛红衍生的Morita-Baylis-Hillman加合物和环状磺酰亚胺为原料，通过有机催化的[3 + 2]成环反应，获得了高产率和良好的对映体和非对映体选择性.该反应提供了获得高度取代的氮杂-螺羟吲哚衍生物的途径，其还含有环稠合的环状磺酰胺。
An organocatalytic [3 + 2]-annulation between isatin-derived Morita–Baylis–Hillman adducts and cyclic sulfonimines has been developed in high yields with excellent enantio- and diastereoselectivities via an allylic nitrogen-ylide intermediate. The reaction provides access to heavily substituted aza-spirooxindole derivatives, which also contain ring fused cyclic sultams.