Circulating Betatrophin Is Increased in Patients with Overt and Subclinical Hypothyroidism.
Circulating Betatrophin Is Increased in Patients with Overt and Subclinical Hypothyroidism.
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明显和亚临床甲状腺功能减退症患者的循环 Betatropin 增加
DOI：
10.1155/2016/5090852
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发表时间：
2016
影响因子：
--
通讯作者：
Teng W
中科院分区：
文献类型：
--
作者：
Han C;Xia X;Liu A;Zhang X;Zhou M;Xiong C;Liu X;Sun J;Shi X;Shan Z;Teng W
甲状腺激素（TH）影响许多代谢过程，如促进许多组织中糖、脂肪和蛋白质的氧化。甲状腺功能障碍与代谢紊乱有关。新发现的脂肪细胞和肝细胞源性细胞因子betatrophin已被报道参与代谢性疾病，但其对甲状腺功能障碍的影响尚不确定。因此，本研究旨在评估不同甲状腺功能状态受试者的循环betatrophin水平，并预测与betatrophin水平相关的因素，特别是促甲状腺激素（TSH），TH或甲状腺自身抗体是否与betatrophin水平相关。在该研究中，根据甲状腺功能，测量了明显甲状腺功能减退症（OH）、亚临床甲状腺功能减退症（SCH）、甲状腺功能正常伴甲状腺过氧化物酶抗体阳性（分离Ab）和健康对照（HC）受试者的血清betatrophin。从我们的研究结果中，我们发现betatrophin可能与甲状腺功能不全有关，但与甲状腺自身免疫无关。因此，在解释betatrophin的结果时，还应考虑甲状腺功能。
Thyroid hormone (TH) affects many metabolic processes such as promoting oxidation of sugar, fat, and protein in many tissues. Thyroid dysfunction is associated with metabolic disorders. The newly discovered adipocyte- and hepatocyte-derived cytokine, betatrophin, has been reported to be involved in metabolic diseases, but its influence on thyroid dysfunction is uncertain. Therefore, the present study aims to evaluate circulating betatrophin levels in subjects with different thyroid function status and to predict the factors associated with betatrophin levels, especially whether thyroid stimulating hormone (TSH), TH, or thyroid autoantibodies are associated with betatrophin levels. In the study, serum betatrophin was measured in the subjects grouped as overt hypothyroidism (OH), subclinical hypothyroidism (SCH), euthyroid with isolated thyroid peroxidase antibody positivity (isolated Ab), and healthy control (HC), according to their thyroid functions. From our results, we found that betatrophin may be associated with thyroid insufficiency but not thyroid autoimmunity. Thus, when interpreting the results of betatrophin, thyroid functions should also be taken into consideration.