Neuropathologic changes in Alzheimer's disease.
Neuropathologic changes in Alzheimer's disease.
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发表时间：
2003-07
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通讯作者：
G. Wenk
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作者：
G. Wenk
阿尔茨海默病的特点是各种神经递质系统的退行性改变。这包括释放谷氨酸、去甲肾上腺素和血清素的单胺能神经系统以及一些神经肽系统功能的改变。阿尔茨海默病的另一个特征是在特定的大脑区域发生退行性变化，包括颞叶和顶叶以及额叶皮层和扣带回内的受限区域。这些系统的退化可能是阿尔茨海默病相关痴呆的特定方面的基础。目前阿尔茨海默病研究的一个主要问题是，目前的假设机制都不能解释阿尔茨海默病神经病理学特征的细胞和区域分布模式。本文总结了与神经系统相关的变化的性质和程度，可能的治疗方法，以及涉及慢性神经炎症的潜在机制，以解释阿尔茨海默病的神经病理变化模式。
Alzheimer's disease is characterized by degenerative changes in a variety of neurotransmitter systems. These include alterations in the function of the monoaminergic neural systems that release glutamate, norepinephrine, and serotonin as well as a few neuropeptide-containing systems. Alzheimer's disease is also characterized by degenerative changes in selected brain regions, including the temporal and parietal lobes and restricted regions within the frontal cortex and cingulate gyrus. The degeneration of these systems may underlie specific aspects of the dementia associated with Alzheimer's disease. A major problem in Alzheimer's disease research today is that none of the current hypothesized mechanisms are able to explain the cellular and regional distribution pattern that characterizes the neuropathology of Alzheimer's disease. This article summarizes the nature and extent of the changes associated with neural systems, possible treatment approaches, and a potential mechanism involving chronic neuroinflammation to explain the pattern of neuropathologic changes in Alzheimer's disease.