Self-splicing RNA and an RNA enzyme in Tetrahymena.
Self-splicing RNA and an RNA enzyme in Tetrahymena.
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四膜虫中的自剪接 RNA 和 RNA 酶。
DOI：
10.1111/j.1550-7408.1987.tb03204.x
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Cech,TR
中科院分区：
文献类型：
--
作者：
Zaug,AJ;Cech,TR
从许多真核基因转录的RNA分子被插入序列中断，这些插入序列通过称为RNA剪接的过程被移除。一组结构相关的插入序列，即第I组插入序列，存在于多种微生物中。其中一些，包括来自嗜热四膜虫核糖体RNA前体的I组间插序列，已被证明在RNA催化反应中介导其自身的剪接。在从核糖体RNA前体切除后，四膜虫间插序列充当酶，切割并重新连接RNA底物。
The RNA molecules transcribed from many eukaryotic genes are interrupted by intervening sequences, which are removed by a process called RNA splicing. One structurally related group of intervening sequences, the group I intervening sequences, are found in a variety of microorganisms. Some of these, including the group I intervening sequence from the ribosomal RNA precursor of Tetrahymena thermophila, have been shown to mediate their own splicing in an RNA-catalyzed reaction. Following its excision from the ribosomal RNA precursor, the Tetrahymena intervening sequence acts as an enzyme, cutting and rejoining RNA substrates.