Randomized comparison of near-infrared fluorescence imaging using indocyanine green and 99(m) technetium with or without patent blue for the sentinel lymph node procedure in breast cancer patients.
Randomized comparison of near-infrared fluorescence imaging using indocyanine green and 99(m) technetium with or without patent blue for the sentinel lymph node procedure in breast cancer patients.
复制标题
DOI：
10.1245/s10434-012-2466-4
复制
发表时间：
2012-12
影响因子：
3.7
通讯作者：
Vahrmeijer AL
中科院分区：
文献类型：
--
作者：
van der Vorst JR;Schaafsma BE;Verbeek FP;Hutteman M;Mieog JS;Lowik CW;Liefers GJ;Frangioni JV;van de Velde CJ;Vahrmeijer AL
Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has the potential to improve sentinel lymph node (SLN) mapping of breast cancer. We performed a randomized clinical trial to assess the value of blue dyes when used in combination with NIR fluorescence. We also preliminarily examined the possibility of performing SLN mapping without radiotracers. Clinical trial subjects were 24 consecutive breast cancer patients scheduled to undergo SLN biopsy. All patients received standard of care using 99m technetium-nanocolloid and received 1.6 mL of 500 μM ICG injected periareolarly. Patients were randomly assigned to undergo SLN biopsy with or without patent blue. To assess the need for radiocolloids to localize the SLN or SLNs, the surgeon did not use the handheld gamma probe during the first 15 min after the axillary skin incision. SLN mapping was successful in 23 of the 24 patients. No significant difference was found in signal-to-background ratio between the groups with and without patent blue (8.3 ± 3.8 vs. 10.3 ± 5.7, respectively, P = 0.32). In both groups, 100 % of SLNs were radioactive and fluorescent, and in the patent blue group, only 84 % of SLNs were stained blue. In 25 % of patients, the use of the gamma probe was necessary to localize the SLN within the first 15 min. This study shows that there is no benefit of using patent blue for SLN mapping in breast cancer patients when using NIR fluorescence and 99m technetium-nanocolloid. NIR fluorescence imaging outperformed patent blue in all patients.
登录
查看更多内容
影响因子：
9.6
作者：
Xing, Y.;Foy, M.;Cormier, J. N.
通讯作者：
Cormier, J. N.
DOI：
10.1016/s0149-7944(02)00618-9
发表时间：
2002-07-01
期刊：
Current surgery
影响因子：
--
作者：
Davis, Kurt G;Schriver, John P
通讯作者：
Schriver, John P
影响因子：
9.6
作者：
Murawa, D.;Hirche, C.;Huenerbein, M.
通讯作者：
Huenerbein, M.
影响因子：
9
作者：
Cox, CE;Pendas, S;Reintgen, DS
通讯作者：
Reintgen, DS
影响因子：
3.8
作者：
Goyal, Amit;Newcombe, Robert G.;Mansel, Robert E.
通讯作者：
Mansel, Robert E.