A Clinical Study on Intellectual Impairment in Parkinsonian Patients during Long‐Term Treatment
A Clinical Study on Intellectual Impairment in Parkinsonian Patients during Long‐Term Treatment
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帕金森病患者长期治疗期间智力障碍的临床研究
DOI：
10.1111/j.1440-1819.1991.tb00500.x
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发表时间：
1991
影响因子：
11.9
通讯作者：
T. Shoda
中科院分区：
文献类型：
--
作者：
J. Horiguchi;O. Nishimatsu;Y. Inami;T. Sukegawa;T. Shoda
摘要：采用大阪老年人智力量表(OISA)对89例帕金森病患者的智能障碍程度进行评估。根据患者的智力水平，将患者分为正常组、轻度痴呆组和痴呆组。还检查了脑电图、精神并发症，如幻觉、运动残疾程度、服药史、智力变化与用药总量的关系。病程长短与智力损害程度无明显相关性。在我们的受试者中发现了两个典型的亚组：一组患者在帕金森症发作后迅速变得精神错乱，另一组患者的智力被保存了更长的一段时间。前者的平均发病年龄大于后者。前一组患者出现精神并发症和脑电异常的频率较高。在OISA检查时，运动障碍的严重程度和药物治疗在两组之间没有差异。帕金森病患者的智力减退与抗帕金森病药物的使用总量无关。
Abstract: The severity of intellectual impairment of 89 patients with Parkinson's disease was evaluated with the Osaka Intelligence Scale for the Aged (OISA). Based on their intelligence levels, the patients were divided into three groups: normal, slight dementia and dementia. EEGs, psychiatric complications such as hallucination, degree of motor disability, history of medication, relationship between changes in intelligence and total amount of administered drugs were also examined. There was no significant correlation between the length of duration of the illness and the degree of intellectual impairment. Two characteristic subgroups were found among our subjects: a group of patients who rapidly became demented after the onset of Parkinsonism, and a group of patients whose intelligence was preserved for a longer period. The mean age of the onset of the disease in the former group was older than that of the latter. Patients of the former group exhibited psychiatric complications and EEG abnormalities more frequently. The severity of motor disability and medications administered at the time of the OISA examination did not differ between the two groups. Deterioration of the intelligence of the patients with Parkinson's disease did not correlate with the total amount of the administered antiparkinsonian drugs.
长期服用左旋多巴后帕金森病的胆碱能和多巴胺能机制。
影响因子：
--
作者：
Clough,CG;Bergmann,KJ;Yahr,MD
通讯作者：
Yahr,MD
帕金森病的痴呆症。
影响因子：
3.3
作者：
Mortimer,JA
通讯作者：
Mortimer,JA