SYNAPTIC REARRANGEMENT IN DENTATE GYRUS - HISTOCHEMICAL EVIDENCE OF ADJUSTMENTS AFTER LESIONS IN IMMATURE AND ADULT RATS
SYNAPTIC REARRANGEMENT IN DENTATE GYRUS - HISTOCHEMICAL EVIDENCE OF ADJUSTMENTS AFTER LESIONS IN IMMATURE AND ADULT RATS
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DOI：
10.1073/pnas.70.12.3473
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发表时间：
1973-01-01
影响因子：
11.1
通讯作者：
LYNCH, G
中科院分区：
文献类型：
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作者：
COTMAN, CW;MATTHEWS, DA;LYNCH, G
在未成熟的动物中，内嗅皮质的消融引起齿状回分子层外四分之一的乙酰胆碱酯酶（EC 3.1.1.7）染色迅速增强。随后的中隔病变消除了这种乙酰胆碱酯酶增强。电镜组织化学分析显示，增强区乙酰胆碱酯酶阳性突触末梢数量增加了30倍。因此，乙酰胆碱酯酶的增加似乎至少部分归因于由间隔海马体纤维建立的富含乙酰胆碱酯酶的突触末梢数量的增加。对未成熟和成年大鼠的比较研究表明，动物的发育状态是这些病变诱导的神经元调节差异的主要决定因素。
In immature animals, ablation of the entorhinal cortex elicited a rapid intensification of acetylcholinesterase (EC 3.1.1.7) staining in the outer one-quarter of the molecular layer of the dentate gyrus. Subsequent lesions of the septum eliminated this acetylcholinesterase intensification. Electron-microscopic histochemical analysis demonstrated a 30-fold increase in the number of acetylcholinesterase-positive synaptic endings in the intensification zone. The acetylcholinesterase augmentation thus appears attributable, in part at least, to an increase in the number of acetylcholinesterase-rich synaptic endings established by septo-hippocampal fibers. Observations in a comparative study of immature and adult rats point to the animal's developmental state as a major determinant of differences in these lesion-induced neuronal adjustments.