Intramolecularly hydrogen-bonded peptide conformations.
Intramolecularly hydrogen-bonded peptide conformations.
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分子内氢键肽构象。
DOI：
10.3109/10409238009105471
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
C. Toniolo
中科院分区：
文献类型：
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作者：
C. Toniolo
近年来，线性肽和环状肽中可能存在的分子内氢键结构引起了越来越多的关注。在这篇综述中，重点是固体的研究，特别是x射线衍射和红外吸收技术。构象能的计算也被考虑。讨论的重点是模型多肽和生物活性多肽分子。所研究的四肽体系（公式：见文本）允许人们讨论扩展的C5结构和各种折叠构象，即C7（-转）、C8、C10（-转）、C11和C13构象。后四种形式可能包括顺式肽构型。还讨论了C7、C10和C13构象的氧类似物和含有分叉氢键的结构。最后一节描述分子内氢键肽结构，包括：(1)侧链基团，(2)n保护基团（在合成模型化合物中），以及(3)β -氨基酸。
Over the past few years the possible occurrence of intramolecularly hydrogen-bonded structures in linear and cyclic peptides has attracted increasing attention. In this review emphasis is given to solid-state studies, particularly by X-ray diffraction and infrared absorption techniques. Conformational energy calculations are also considered. The discussion is focused both on model peptides and biological activity polypeptide molecules. The tetrapeptide system (Formula: see text), examined allows one to discuss the extended C5 structure and the various folded conformations, namely the C7 (gamma-turn), C8, C10 (beta-turn), C11, and C13 conformations. The four latter forms may include cis peptide configurations. The oxy-analogs to the C7, C10, and C13 conformations and structures containing bifurcated hydrogen bonds are also discussed. The last sections describe intramolecularly hydrogen-bonded peptide structures involving: (1) a side-chain group, (2) the N-protecting group (in synthetic model compounds), and (3) a beta-amino acid.