Age-related neuronal loss in the submucosal plexus of the colon of Fischer 344 rats.
Age-related neuronal loss in the submucosal plexus of the colon of Fischer 344 rats.
复制标题
Fischer 344 大鼠结肠粘膜下神经丛中与年龄相关的神经元损失。
DOI：
10.1016/j.neurobiolaging.2006.05.019
复制
发表时间：
2007
影响因子：
4.2
通讯作者：
Powley,TerryL
中科院分区：
文献类型：
--
作者：
Phillips,RobertJ;Pairitz,JulieC;Powley,TerryL
The submucosal plexus (SMP) of the large intestine plays important roles in secretion and motility, functions that are compromised in the aged. To determine the effects of aging on intrinsic SMP neurons and their extrinsic inputs, whole mounts from the colon of ad libitum fed virgin male Fischer 344 rats ranging in age from 6 to 27 months were processed to visualize neurons and nerve fibers immunoreactive for either tyrosine hydroxylase (TH-IR) or calcitonin gene-related peptide (CGRP-IR). Significant age-related loss of SMP neurons occurred as early as 12 months of age and progressed in a roughly linear manner with age, dropping, for example, by 38% in the distal colon. In aging rats, the colonic SMP routinely contained markedly swollen TH-IR axons and terminals and exhibited a reduction of ganglionic neuropil, whereas CGRP-IR fibers evidenced only modest axonopathies. These findings point to selective deterioration of the SMP and its extrinsic inputs as one possible mechanism for the age-related decline in large intestinal function evidenced in the elderly.
