Levels of aqueous humor trace elements in patients with non-exsudative age-related macular degeneration: a case-control study.
Levels of aqueous humor trace elements in patients with non-exsudative age-related macular degeneration: a case-control study.
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DOI：
10.1371/journal.pone.0056734
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Rejdak R
中科院分区：
文献类型：
--
作者：
Jünemann AG;Stopa P;Michalke B;Chaudhri A;Reulbach U;Huchzermeyer C;Schlötzer-Schrehardt U;Kruse FE;Zrenner E;Rejdak R
微量元素可能在老年性黄斑变性(AMD)复杂的多因素发病机制中发挥作用。本研究的目的是检测非渗出性(干性)AMD患者房水中微量元素水平的变化。在这项初步研究中，房水样本采集自接受白内障手术的患者。干性AMD患者12例(年龄77.9±6.62岁，女性8例，男性4例)和非AMD患者11例(年龄66.6±16.7岁，女性7例，男性4例)。水中镉、钴、铜、铁、锰、硒和锌的含量用Flow-Injection-Inductively-Coupled-Plasma-Mass-Spectrometry(FI-ICPMS)测量，质量控制在认证的标准下。老年性黄斑变性患者房水中镉(中位数：0.7µm ol/L，IQR0.40-0.84vs.0.06µm o l/L；IQR0.01-0.018；p = 0.002)、钴(中位数：3.1µm o l/L，IQR2.62-3.15vs.1.17µm o l/L；IQR0.95-1.27；p<；0.001)、铁(中位数：311µm o l/L，IQR289-329 vs.129µm o l/L；IQR111-145；P<；0.001)和锌(中位数：23.1um ol/L，智商：12.9-32.6vs.5.1µm o l/L；智商：4.4-9.4；p = 0.020)。与非AMD患者相比，AMD患者的铜水平显著降低(中位数：16.2微克分子/L，IQR11.4-31.3vs.49.9微克分子/L；IQR32.0-.142.0；p = 0.022)。在患有和不患有AMD的患者之间，房水中的锰和硒水平没有显著差异。在对多项测试进行调整后，镉、钴、铜和铁仍然是AMD GLM模型(根据患者的年龄和性别进行调整)中的一个重要因素。微量元素水平的变化支持镉、钴、铁和铜参与AMD发病机制的假说。
Trace elements might play a role in the complex multifactorial pathogenesis of age-related macular degeneration (AMD). The aim of this study was to measure alterations of trace elements levels in aqueous humor of patients with non-exsudative (dry) AMD. For this pilot study, aqueous humor samples were collected from patients undergoing cataract surgery. 12 patients with dry AMD (age 77.9±6.62, female 8, male 4) and 11 patients without AMD (age 66.6±16.7, female 7, male 4) were included. Aqueous levels of cadmium, cobalt, copper, iron, manganese, selenium, and zinc were measured by use of Flow-Injection-Inductively-Coupled-Plasma-Mass-Spectrometry (FI-ICP-MS), quality controlled with certified standards. Patients with AMD had significantly higher aqueous humor levels of cadmium (median: 0.70 µmol/L, IQR: 0.40–0.84 vs. 0.06 µmol/L; IQR: 0.01–.018; p = 0.002), cobalt (median: 3.1 µmol/L, IQR: 2.62–3.15 vs. 1.17 µmol/L; IQR: 0.95–1.27; p<0.001), iron (median: 311 µmol/L, IQR: 289–329 vs. 129 µmol/L; IQR: 111–145; p<0.001) and zinc (median: 23.1 µmol/L, IQR: 12.9–32.6 vs. 5.1 µmol/L; IQR: 4.4–9.4; p = 0.020) when compared with patients without AMD. Copper levels were significantly reduced in patients with AMD (median: 16.2 µmol/L, IQR: 11.4–31.3 vs. 49.9 µmol/L; IQR: 32.0–.142.0; p = 0.022) when compared to those without. No significant differences were observed in aqueous humor levels of manganese and selenium between patients with and without AMD. After an adjustment for multiple testing, cadmium, cobalt, copper and iron remained a significant factor in GLM models (adjusted for age and gender of the patients) for AMD. Alterations of trace element levels support the hypothesis that cadmium, cobalt, iron, and copper are involved in the pathogenesis of AMD.
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