The Effect of Low Humidity on the Human Tear Film
The Effect of Low Humidity on the Human Tear Film
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DOI：
10.1097/ico.0b013e31826671ab
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发表时间：
2013-04-01
期刊：
影响因子：
2.8
通讯作者：
Pearce, E. Ian
中科院分区：
文献类型：
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作者：
Abusharha, Ali A.;Pearce, E. Ian
目的：目的：研究低相对湿度环境对泪膜生理的影响。方法：采用可控环境箱，建立两种不同的环境条件。环境温度在两种条件下都是恒定的（21 ℃），而RH在正常条件下设定为40%，在干燥环境下设定为5%。在正常湿度和干燥环境中60分钟内评估泪液蒸发、非侵入性泪液破裂时间、脂质层厚度（LLT）、渗透压、眼部舒适度、泪液产生和眼表温度。泪液蒸发率有明显变化（P = 0.00）、非侵入性泪膜破裂时间（P = 0.00）、LLT（P = 0.00）、眼部舒适度（P = 0.00）和泪液分泌（P = 0.01）。正常和干燥的环境条件下，泪液渗透压（P = 0.09）和眼表温度（P = 0.20）之间没有显着差异，观察结论：蒸发率，眼泪LLT，眼睛舒适度，泪液稳定性，和生产的不利影响，低RH。暴露于干燥环境1小时后观察到的泪膜参数与干眼患者的参数相似。因此，为了避免泪膜破坏和可能的眼表面损伤，需要改善干燥位置的环境条件，或者应该保护泪膜免受不利的环境条件的影响。
Purpose: To investigate the effect of exposure to a low relative humidity (RH) environment on tear film physiology.Method: A controlled environment chamber was used to create 2 different environmental conditions. Ambient temperature was constant in both conditions (21 degrees C) while the RH was set at 40% at the normal condition and at 5% in the desiccating environment. Tear evaporation, noninvasive tear break-up time, lipid layer thickness (LLT), osmolarity, ocular comfort, tear production, and ocular surface temperature were assessed in normal humidity and over a period of 60 minutes in the dry environment.Results: There was significant change in tear evaporation rate (P = 0.00), noninvasive tear break-up time (P = 0.00), LLT (P = 0.00), ocular comfort (P = 0.00), and tear production (P = 0.01) after exposure to the desiccating environment. No significant differences were observed between normal and dry environmental conditions in tear osmolarity (P = 0.09) and ocular surface temperature (P = 0.20).Conclusions: Evaporation rate, tear LLT, ocular comfort, tear stability, and production were adversely affected by low RH. The tear film parameters observed after exposure to a desiccating environment for 1 hour were similar to those of the dry eye patient. Therefore, to avoid tear film disruption and possible ocular surface damage, the environmental conditions of dry locations need to be improved or the tear film should be protected against adverse environmental conditions.