The common properties of neurogenesis in the adult brain: from invertebrates to vertebrates
The common properties of neurogenesis in the adult brain: from invertebrates to vertebrates
复制标题
DOI：
10.1016/s1096-4959(01)00525-5
复制
发表时间：
2002-05-01
影响因子：
2.2
通讯作者：
Strambi, A
中科院分区：
文献类型：
--
作者：
Cayre, M;Malaterre, J;Strambi, A
直到最近，人们还认为成年人的大脑不能产生任何新的神经元。然而，现在人们普遍知道干细胞仍然存在于成年中枢神经系统中，成年脊椎动物和成年无脊椎动物目前正在其中枢神经系统的一些特殊结构中添加新的神经元。脊椎动物的脑室下区和海马齿状回是神经元前体增殖的部位。在一些昆虫中，持续的神经发生发生在蘑菇体中，蘑菇体是参与学习和记忆的大脑结构，被认为是海马体的功能类似物。在脊椎动物和无脊椎动物中，次级神经发生(包括神经母细胞增殖和神经元分化)似乎受到激素、递质、生长因子和环境信号的调节。成体神经发生的功能含义尚未得到明确的论证，对各种模型系统的比较研究有助于更好地理解这一现象。在这里，我们回顾和讨论了迄今为止所研究的各种动物模型中成体神经发生的共同特征。(C)2002 Elsevier Science Inc.保留所有权利。
Until recently, it was believed that adult brains were unable to generate any new neurons. However, it is now commonly known that stem cells remain in them adult central nervous system and that adult vertebrates as well as adult invertebrates are currently adding new neurons in some specialized structures of their central nervous system. In vertebrates, the subventricular zone and the dentate gyrus of the hippocampus are the sites of neuronal precursor proliferation. In some insects, persistent neurogenesis occurs in the mushroom bodies, which are brain structures involved in learning and memory and considered as functional analogues of the hippocampus. In both vertebrates and invertebrates, secondary neurogenesis (including neuroblast proliferation and neuron differentiation) appears to be regulated by hormones, transmitters, growth factors and environmental cues. The functional implications of adult neurogenesis have not yet been clearly demonstrated and comparative study of the various model systems could contribute to better understand this phenomenon. Here, we review and discuss the common characteristics of adult neurogenesis in the various animal models studied so far. (C) 2002 Elsevier Science Inc. All rights reserved.