MicroRNA-based screens for synthetic lethal interactions with c-Myc.
MicroRNA-based screens for synthetic lethal interactions with c-Myc.
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DOI：
10.14800/rd.1330
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发表时间：
2016-05
期刊：
影响因子：
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通讯作者：
Youjun Li;Yahui Zhu;E. Prochownik
中科院分区：
文献类型：
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作者：
Youjun Li;Yahui Zhu;E. Prochownik
MicroRNAs(MiRs)是一种小的、非编码的RNA，在人类癌症的发生和发展中发挥着至关重要的作用。鉴于miRs是稳定的，易于合成，并且容易被引入细胞，它们被认为在癌症方面具有潜在的治疗益处。C-Myc(Myc)是最常见的去调控的癌基因转录因子之一，在癌症的发病机制中具有重要作用，因此成为一个重要的治疗靶点。在这里，我们回顾了已被确定为Myc的正靶和负靶的miRs，以及它们如何参与Myc驱动的转化所产生的复杂表型。我们还讨论了最近关于Myc合成的与miR的致命性相互作用的几篇报道，这些报道突出了miRs在Myc介导的生物学功能中的重要性和复杂性，以及Myc驱动的人类癌症治疗的机会。
microRNAs (miRs) are small, non-coding RNAs, which play crucial roles in the development and progression of human cancer. Given that miRs are stable, easy to synthetize and readily introduced into cells, they have been viewed as having potential therapeutic benefit in cancer. c-Myc (Myc) is one of the most commonly deregulated oncogenic transcription factors and has important roles in the pathogenesis of cancer, thus making it an important, albeit elusive therapeutic target. Here we review the miRs that have been identified as being both positive and negative targets for Myc and how these participate in the complex phenotypes that arise as a result of Myc-driven transformation. We also discussseveral recent reports of Myc-synthetic lethal interactions with miRs.These highlight the importance and complexity of miRs in Myc-mediated biological functions and the opportunities for Myc-driven human cancer therapies.