Sugar and Fat Bingeing Have Notable Differences in Addictive-like Behavior
Sugar and Fat Bingeing Have Notable Differences in Addictive-like Behavior
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DOI：
10.3945/jn.108.097584
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发表时间：
2009-03-01
影响因子：
4.2
通讯作者：
Hoebel, Bartley G.
中科院分区：
文献类型：
--
作者：
Avena, Nicole M.;Rada, Pedro;Hoebel, Bartley G.
摄入不同的营养物质，如脂肪和糖，通常会对生理、大脑和行为产生不同的影响。然而，它们确实共享某些强化行为的神经通路，包括中脑边缘多巴胺（DA）系统。当这些营养物质以暴饮暴食的形式被消耗时，就会释放出过量的DA，从而引起代偿性变化，其效果堪比滥用药物。在本文中，我们回顾了从脂肪和糖暴饮暴食动物模型中获得的数据。从临床和实验动物的角度描述和回顾了“食物成瘾”的概念。对糖和脂肪暴饮暴食的成瘾样行为和伴随的DA和阿片系统改变的行为表现进行了比较。最后，关于饮食失调和肥胖，我们讨论了脂肪可能是导致超重的大量营养素，而没有脂肪的甜味可能在很大程度上导致了包括戒断综合症在内的成瘾行为。中国生物医学工程学报，21(3):623-628,2009。
Ingestion of different nutrients, such as fats and sugars, normally produces different effects on physiology, the brain, and behavior. However, they do share certain neural pathways for reinforcement of behavior, including the mesolimbic dopamine (DA) system. When these nutrients are consumed in the form of binges, this can release excessive DA, which causes compensatory changes that are comparable to the effects of drugs of abuse. In this article, we review data obtained with animal models of fat and Sugar bingeing. The concept of "food addiction" is described and reviewed from both clinical and laboratory animal perspectives. Behavioral manifestations of addictive-like behavior and concomitant alterations in DA and opioid systems are compared for sugar and fat bingeing. Finally, in relation to eating disorders and obesity, we discuss how fat may be the macronutrient that results in excess body weight, and sweet taste in the absence of fat may be largely responsible for producing addictive-like behaviors that include a withdrawal syndrome. J. Nutr. 139: 623-628, 2009.