von Economo encephalitis
von Economo encephalitis
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DOI：
10.1001/archneur.58.10.1696
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发表时间：
2001-10-01
影响因子：
--
通讯作者：
Dickman, MS
中科院分区：
文献类型：
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作者：
Dickman, MS
1917 年 4 月，康斯坦丁·冯·伊科诺莫 (Constantin von Economo) 博士在维也纳精神病学会面前介绍了他对一种新疾病（很快将成为全球流行病的一部分）的临床和病理学发现。他将其命名为昏睡性脑炎。经过多年的仔细观察，他收集并分析了数千例病例，并将其分为3种临床综合征：嗜睡性眼肌麻痹型、运动亢进型和肌静止型运动不能型。他描述了现在传奇的脑炎后帕金森病，并指出症状可能在最初感染后数年出现，通常没有前驱“流感”的迹象。他强调了神经病理学发现：被盖的炎症变化。中脑负责睡眠障碍和眼部症状。在接触到疫情后的散发病例后，他得出结论，嗜睡性眼肌麻痹综合征是昏睡性脑炎的主要表现。本文通过主要引用自冯·伊科诺莫博士已发表的作品以及最近的报告的重要引文，概述了冯·伊科诺莫博士在疫情期间和之后的观察和结论。
In April 1917, Dr Constantin von Economo presented his clinical and pathologic findings of a new disease-soon to be part of a worldwide epidemic-before the Vienna Psychiatric Society. He named it encephalitis lethargica. After years of careful observation, he collected and analyzed thousands of cases and classified them into 3 clinical syndromes: somnolent-ophthalmoplegic, hyperkinetic, and amyostatic-akinetic forms. He described the now legendary postencephalitic Parkinsonism, noting that symptoms could emerge years after the original infection, often without signs of prodromal "flu." He emphasized the neuropathologic findings: inflammatory changes in the tegmentum. of the midbrain accounting for the sleep disturbance and ocular signs. After encountering sporadic cases following the epidemic, he concluded that the somnolent-ophthalmoplegic syndrome was the primary expression of encephalitis lethargica. This article outlines the observations and conclusions of Dr von Economo during and after the epidemic through seminal quotations primarily from his published works, as well as from more recent reports.