Zone I retinopathy of prematurity
Zone I retinopathy of prematurity
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DOI：
10.1067/mpa.2000.107904
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发表时间：
2000-12-01
期刊：
影响因子：
1.6
通讯作者：
Dorta, P
中科院分区：
文献类型：
--
作者：
Katz, X;Kychenthal, A;Dorta, P
引言：I区早产儿视网膜病变（ROP）患者尽管接受了治疗，但预后不良。我们分析了I区疾病患者的临床特征和治疗结果，并与II区疾病患者进行了比较。方法：作者筛选出生时体重小于1500 g的早产儿，年龄为4~6周（A组）。B组由在其他地方接受过筛查的转诊患者组成。根据早产儿视网膜病变国际分类记录结果。我们将所有患者分为I区、II区或III区疾病。如果视网膜病变在一只眼睛中跨越2个区域，则根据早产儿视网膜病变国际分类将其分类在最后区。阈值的定义与早产儿视网膜病变冷冻治疗研究相同。间接半导体激光治疗用于消融无血管视网膜。在3个月随访时，根据早产儿视网膜病变冷冻治疗标准判断结局。分析I区或II区ROP眼之间的差异。结果如下：B组63例，其中I区ROP 9例，共11例22眼。在3个月时，纳入随访的20只I区ROP眼中有8只（40%）结局不利。I区和II区病例的平均出生体重和胎龄相似，但治疗时的平均胎龄有显著差异（I区病例为35.2周，II区病例为37.2周，P = 0.006）。不寻常的迹象，如血管和无血管视网膜之间的分界血管和过度的视网膜内新生血管在I区眼睛中观察到，但在II区或III区ROP的眼睛中没有观察到讨论：I区ROP似乎不同于II区ROP。应特别注意I区ROP中存在的非典型形态。
Introduction: Patients with zone I retinopathy of prematurity(ROP) have poor outcomes despite treatment. We analyze the clinical characteristics and treatment outcome of patients with zone I disease and compare them with patients with zone II disease. Methods: Preterm infants weighing less than 1500 g at birth were screened by the authors at age 4 to 6 weeks (group A). Group B was composed of referral patients that had been screened elsewhere. Findings were recorded according to the International Classification of Retinopathy of Prematurity. We classified all patients as either zone I, zone II, or zone III disease. If a retinopathy spanned 2 zones in one eye, it was classified in the most posterior zone as indicated by the International Classification of Retinopathy of Prematurity. Threshold was defined as in the Cryotherapy for Retinopathy of Prematurity study. Indirect diode-laser treatment was used to ablate the avascular retina. At the 3-month follow-up, outcome was judged according to Cryotherapy for Retinopathy of Prematurity criteria. Differences between eyes with zone I or zone II ROP were analyzed. Results: Group A was composed of 222 infants; 2 presented with zone I ROP Of 63 patients comprising group B, 9 had zone I ROP: a total of 11 infants with zone I ROP, 22 eyes. At 3 months, 8 of 20 eyes with zone I ROP that were included in follow-up had an unfavorable outcome (40%). Mean birth weight and gestational age were similar in zone I and zone II cases, but mean gestational age at treatment was significantly different (35.2 weeks in zone I cases vs 37.2 weeks in zone II cases, P=.006). Unusual signs such asa demarcation vessel between vascular and avascular retina and excessive intraretinal neovascularization were observed in zone I eyes but not observed in eyes with zone II or zone III ROP Discussion: Zone I ROP appears to be different from zone II ROP Earlier treatment age suggests either an early start, faster progression, or both. Special attention should be given to atypical morphology present in zone I ROP.