POPULATION SIZE AND PROTEIN VARIATION IN MAN
POPULATION SIZE AND PROTEIN VARIATION IN MAN
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DOI：
10.1017/s0016672300014282
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发表时间：
1972-01-01
期刊：
影响因子：
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通讯作者：
SMITH, JM
中科院分区：
文献类型：
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作者：
HAIGH, J;SMITH, JM
“中性突变理论”认为，进化中的大多数氨基酸取代都是选择性中性的。只有当人类在最近经历过数量瓶颈时，已知的人类血红蛋白变异模式才能与这一理论相一致。如果这个理论成立，就可以估计这个瓶颈的必要规模和持续时间。一种理论的发展导致了对 Yg、n 的估计，即 g 代和 n 代之前出现的群体中存在的等位基因的数量，从而得出估计，其中 u 是中性突变率，Ne 是有效群体大小，即群体不包含此类等位基因的概率。使用血红蛋白的数据，这给出了自人口数量瓶颈以来所经过的时间的近似上限。要么出现了这样的瓶颈，要么中性突变理论是错误的；其他蛋白质的数据将使我们能够在这些可能性之间做出选择。
The ‘neutral mutation theory’ holds that most amino acid substitutions in evolution are selectively neutral. The known pattern of variation in human haemoglobins can only be made consistent with this theory if the human species has passed through a bottleneck of numbers in the recent past. If this theory is true, estimates of the necessary size and duration of this bottleneck can be made. A theory is developed which leads to an estimate of Yg, n, the number of alleles present in a population which arise between g and n generations ago, and hence to the estimatewhere u is the neutral mutation rate and Ne the effective population size, for the probability that a population contains no such alleles. Using data on haemoglobins, this gives an approximate upper limit to the time elapsed since the bottleneck in human numbers. Either such a bottleneck occurred, or the neutral mutation theory is false; data on other proteins will enable a choice between these possibilities to be made.