High CC chemokine receptor 7 expression improves postoperative prognosis of lung adenocarcinoma patients.
High CC chemokine receptor 7 expression improves postoperative prognosis of lung adenocarcinoma patients.
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DOI：
10.1038/bjc.2013.440
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发表时间：
2013-09-03
影响因子：
8.8
通讯作者：
Kimura, H.
中科院分区：
文献类型：
--
作者：
Itakura, M.;Terashima, Y.;Shingyoji, M.;Yokoi, S.;Ohira, M.;Kageyama, H.;Matui, Y.;Yoshida, Y.;Ashinuma, H.;Moriya, Y.;Tamura, H.;Harigaya, K.;Matushima, K.;Iizasa, T.;Nakagawara, A.;Kimura, H.
趋化因子和趋化因子受体不仅在肿瘤转移和肿瘤发生中发挥重要作用，而且还具有抗肿瘤作用。CRKL基因编码的Crk样适配子蛋白(CrkL)与非受体酪氨酸激酶c-ABL相互作用，使许多细胞转化为恶性细胞。我们检测了CC趋化因子受体7(CCR7)、CCR7配体以及CrkL和c-ABL在肺腺癌中的作用。120名肺腺癌患者纳入了这项历史队列分析。我们检测了手术切除的肺腺癌标本中CCR7和CCR7配体、CrkL和c-ABL的mRNA表达，并探讨它们对预后的影响及其与表皮生长因子受体(EGFR)和TP53突变的关系。CCR7mRNA高表达组预后优于低表达组(P=0.007，HR=2.00，95%CI：1.2 2~3.31)。在肺腺癌中，CrkL和c-abl基因的表达与CCR7mRNA的表达相关(P<；0.0001)。EGFR突变对CrkL和c-ABL基因的表达有影响。CCL19高表达是肺腺癌良好的预后因素。我们认为CCR7和CCL19是临床上良好的预后因素，CCR7与肺腺癌中CrkL和c-ABL激酶基因的表达密切相关。
Chemokines and chemokine receptors not only have significant roles in cancer metastasis and tumorigenesis but also act as antitumour agents. The interaction between the Crk-like adaptor protein (CrkL), which is encoded by the CRKL gene, and non-receptor tyrosine kinase c-ABL is reported to transform many cells into malignant cells. We examined the effects of CC chemokine receptor 7 (CCR7), CCR7 ligands and CrkL and c-ABL in lung adenocarcinoma. One hundred and twenty patients with lung adenocarcinoma were included in this historical cohort analysis. We examined CCR7 and CCR7 ligands and CrkL and c-ABL mRNA expressions in surgically resected lung adenocarcinoma specimens and evaluated their contribution to prognosis, and the relationship with epidermal growth factor receptor (EGFR) and TP53 mutations. High CCR7 mRNA expressions indicated better prognoses than those of the groups with low CCR7 mRNA expressions (P=0.007, HR=2.00, 95% CI of ratio: 1.22 –3.31). In lung adenocarcinoma, CrkL and c-ABL mRNAs were related to CCR7 mRNA expression (P<0.0001). CrkL and c-ABL mRNA expressions were influenced by EGFR mutations. A high expression of CCL19 was a good prognostic factor of lung adenocarcinoma. We propose that CCR7 and CCL19 are clinically good prognostic factors and that CCR7 is strongly related to CrkL and c-ABL kinase mRNA expression in lung adenocarcinoma.
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