PREVALENCE OF HYPERHOMOCYST(E)INEMIA IN PATIENTS WITH PERIPHERAL ARTERIAL OCCLUSIVE DISEASE
PREVALENCE OF HYPERHOMOCYST(E)INEMIA IN PATIENTS WITH PERIPHERAL ARTERIAL OCCLUSIVE DISEASE
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DOI：
10.1161/01.cir.79.6.1180
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发表时间：
1989-06-01
期刊：
影响因子：
37.8
通讯作者：
UPSON, B
中科院分区：
文献类型：
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作者：
MALINOW, MR;KANG, SS;UPSON, B
采用一种适用于自动测定的微法测量血浆中均囊(e)氨酸的基础水平[H(e)]。这些水平包括自由和结合形式的同型半胱氨酸、其二硫氧化产物、同型半胱氨酸和同型半胱氨酸-半胱氨酸-混合二硫的总和。研究对象分为两组：表面健康个体（n=103）和外周动脉闭塞性疾病（PAOD）患者（n=47）。由于pad患者的年龄高于对照组，因此将对照组细分为年轻组和老年组（分别为60岁以下和60岁以上）。年轻组H(e)水平为11.18 +-。3.58（平均值+-）SD，表达为同型半胱氨酸)和8.58 .+-。男性和女性分别为2.82 nmol/ml；在老年组中，该水平为10.74 +-。2.16和9.04 .+-。男性和女性分别为2.16 nmol/ml。对照组年轻女性H(e)水平与年龄呈正相关（r=0.373, p < 0.02）；其他三个对照组无显著相关性。pad患者H(e)水平(15.44。5.76和17.04 .+-。（男性和女性分别为8.26 nmol/ml），显著高于上述老年对照组。接下来，将pad患者分为两个亚组：1)H(e)水平正常（在对照组平均值的两个标准差内）的患者和2)H(e)水平升高的患者。年龄、胆固醇血症、吸烟和糖尿病患病率在两个亚组中相似。这些结果提示血浆H(e)升高是动脉闭塞性疾病的独立危险因素。
A micromethod adapated for automated determinations was used to measure basal plasma levels of homocyst(e)ine [H(e)]. These levels included the sum of free and bound forms of homocysteine, its disulfide oxidation product, homocystine, and the homocysteine-cysteine-mixed disulfide. Two groups of subjects were studied: apparently healthy individuals (n=103) and patients with peripheral arterial occlusive disease (PAOD) (n=47). Because age in PAOD patients was higher than in control subjects, the control subjects were subdivided into younger and older groups (aged 60 years or less and more than 60 years, respectively). The H(e) levels in the younger groups were 11.18 .+-. 3.58 (mean .+-. SD, expressed as homocysteine) and 8.58 .+-. 2.82 nmol/ml in men and women, respectively; in the older groups, the levels were 10.74 .+-. 2.16 and 9.04 .+-. 2.16 nmol/ml in men and women, respectively. There was a positive correlation of H(e) levels with age in the younger control women (r=0.373; p < 0.02); no significant correlations were present in the other three control groups. Levels of H(e) in PAOD patients (15.44 .+-. 5.76 and 17.04 .+-. 8.26 nmol/ml in men and women, respectively) were significantly higher than those indicated above in the older controls. Next, the PAOD patients were assigned to two subgroups: 1) those with normal levels of H(e) (within two standard deviations of the mean of the control values) and 2) those with elevated levels of H(e). Age, cholesterolemia, and the prevalence of smoking and diabetes were similar in both subgroups. These results suggest that elevated plasma H(e) is an independent risk factor for arterial occlusive disease.